Gradients in the biophysical properties of neonatal auditory neurons align with synaptic contact position and the intensity coding map of inner hair cells.
auditory nerve
biophysics
developmental gradients
intensity coding
neuroscience
patch-clamp methodology
rat
spiral-ganglion neurons
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 07 2020
08 07 2020
Historique:
received:
22
01
2020
accepted:
24
06
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Sound intensity is encoded by auditory neuron subgroups that differ in thresholds and spontaneous rates. Whether variations in neuronal biophysics contributes to this functional diversity is unknown. Because intensity thresholds correlate with synaptic position on sensory hair cells, we combined patch clamping with fiber labeling in semi-intact cochlear preparations in neonatal rats from both sexes. The biophysical properties of auditory neurons vary in a striking spatial gradient with synaptic position. Neurons with high thresholds to injected currents contact hair cells at synaptic positions where neurons with high thresholds to sound-intensity are found in vivo. Alignment between in vitro and in vivo thresholds suggests that biophysical variability contributes to intensity coding. Biophysical gradients were evident at all ages examined, indicating that cell diversity emerges in early post-natal development and persists even after continued maturation. This stability enabled a remarkably successful model for predicting synaptic position based solely on biophysical properties.
Identifiants
pubmed: 32639234
doi: 10.7554/eLife.55378
pii: 55378
pmc: PMC7343388
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC015512
Pays : United States
Organisme : NIDCD NIH HHS
ID : R03 DC012632
Pays : United States
Organisme : NIH HHS
ID : R01DC015512
Pays : United States
Informations de copyright
© 2020, Markowitz and Kalluri.
Déclaration de conflit d'intérêts
AM, RK No competing interests declared
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