Modeling melanopsin-mediated effects of light on circadian phase, melatonin suppression, and subjective sleepiness.
circadian rhythm
ipRGC
light spectrum
melatonin
monochromatic
nonvisual effects of light
polychromatic
Journal
Journal of pineal research
ISSN: 1600-079X
Titre abrégé: J Pineal Res
Pays: England
ID NLM: 8504412
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
22
04
2020
revised:
05
06
2020
accepted:
01
07
2020
pubmed:
9
7
2020
medline:
30
7
2021
entrez:
9
7
2020
Statut:
ppublish
Résumé
A physiologically based model of arousal dynamics is improved to incorporate the effects of the light spectrum on circadian phase resetting, melatonin suppression, and subjective sleepiness. To account for these nonvisual effects of light, melanopic irradiance replaces photopic illuminance that was used previously in the model. The dynamic circadian oscillator is revised according to the melanopic irradiance definition and tested against experimental circadian phase resetting dose-response and phase response data. Melatonin suppression function is recalibrated against melatonin dose-response data for monochromatic and polychromatic light sources. A new light-dependent term is introduced into the homeostatic weight component of subjective sleepiness to represent the direct alerting effect of light; the new term responds to light change in a time-dependent manner and is calibrated against experimental data. The model predictions are compared to a total of 14 experimental studies containing 26 data sets for 14 different spectral light profiles. The revised melanopic model shows on average 1.4 times lower prediction error for circadian phase resetting compared to the photopic-based model, 3.2 times lower error for melatonin suppression, and 2.1 times lower error for subjective sleepiness. Overall, incorporating melanopic irradiance allowed simulation of wavelength-dependent responses to light and could explain the majority of the observations. Moving forward, models of circadian phase resetting and the direct effects of light on alertness and sleep need to use nonvisual photoreception-based measures of light, for example, melanopic irradiance, instead of the traditionally used illuminance based on the visual system.
Substances chimiques
Rod Opsins
0
melanopsin
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12681Subventions
Organisme : Australian Research Council
ID : FL140100025
Organisme : Cooperative Research Centre for Alertness, Safety and Productivity
Organisme : Australian Research Council, Centre of Excellence for Integrative Brain Function
ID : CE140100007
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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