RIFM fragrance ingredient safety assessment, ethyl (E)hex-3-enoate, CAS registry number 26553-46-8.
And reproductive
Developmental
Environmental safety
Genotoxicity
Local
Phototoxicity/photoallergenicity
Repeated dose
Respiratory toxicity
Skin sensitization
Toxicity
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
15 Oct 2020
15 Oct 2020
Historique:
received:
03
02
2020
revised:
18
05
2020
accepted:
27
05
2020
pubmed:
9
7
2020
medline:
11
5
2021
entrez:
9
7
2020
Statut:
ppublish
Résumé
The existing information supports the use of this material as described in this safety assessment. Ethyl (E)hex-3-enoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl 3-hexenoate (CAS # 2396-78-3) show that ethyl (E)hex-3-enoate is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to ethyl (E)hex-3-enoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using Dermal Sensitization Threshold (DST) for non-reactive materials (900 μg/cm
Identifiants
pubmed: 32640340
pii: S0278-6915(20)30364-1
doi: 10.1016/j.fct.2020.111474
pii:
doi:
Substances chimiques
Caproates
0
Perfume
0
ethyl hexanoate
FLO6YR1SHT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111474Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.