Pharmacokinetics and Metabolism of Liposome-Encapsulated 2,4,6-Trihydroxygeranylacetophenone in Rats Using High-Resolution Orbitrap Liquid Chromatography Mass Spectrometry.
Acetophenones
/ administration & dosage
Administration, Oral
Animals
Biological Availability
Chromatography, Liquid
/ methods
Injections, Intraperitoneal
Liposomes
/ administration & dosage
Male
Phloroglucinol
/ administration & dosage
Plasma
/ chemistry
Rats
Rats, Sprague-Dawley
Tandem Mass Spectrometry
/ methods
LC-HRMS method validation
liposomes
metabolism
pharmacokinetics
trihydroxygeranylacetophenone
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Jul 2020
06 Jul 2020
Historique:
received:
30
04
2020
revised:
17
05
2020
accepted:
20
05
2020
entrez:
10
7
2020
pubmed:
10
7
2020
medline:
16
3
2021
Statut:
epublish
Résumé
2,4,6-trihydroxy-3-geranylacetophenone (tHGA) is a bioactive compound that shows excellent anti-inflammatory properties. However, its pharmacokinetics and metabolism have yet to be evaluated. In this study, a sensitive LC-HRMS method was developed and validated to quantify tHGA in rat plasma. The method showed good linearity (0.5-80 ng/mL). The accuracy and precision were within 10%. Pharmacokinetic investigations were performed on three groups of six rats. The first two groups were given oral administrations of unformulated and liposome-encapsulated tHGA, respectively, while the third group received intraperitoneal administration of liposome-encapsulated tHGA. The maximum concentration (C
Identifiants
pubmed: 32640512
pii: molecules25133069
doi: 10.3390/molecules25133069
pmc: PMC7412073
pii:
doi:
Substances chimiques
2,4,6-trihydroxy-3-geranylacetophenone
0
Acetophenones
0
Liposomes
0
Phloroglucinol
DHD7FFG6YS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Higher Education, Malaysia
ID : FRGS/1/2018/SKK06/UPM/01/1
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