Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine.
metformin
obesity
oxidative-stress
pediatrics
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
06 Jul 2020
06 Jul 2020
Historique:
received:
28
05
2020
revised:
30
06
2020
accepted:
01
07
2020
entrez:
10
7
2020
pubmed:
10
7
2020
medline:
10
7
2020
Statut:
epublish
Résumé
The present study assessed the relationship between obesity induced by lifestyle and systemic oxidative stress and possible modulations by oral metformin treatments in young individuals, by using a translational swine model of obesity and associated cardiometabolic disorders (Iberian pig). The results indicate the existence of an age-related increase in both adiposity and systemic oxidative stress (using hydrogen peroxide as a marker), which is higher in individuals with obesogenic lifestyle and increased weight and obesity. Such effect was not found in individuals treated with metformin. The translation of these results suggests that childhood obesity increases production of reactive oxygen species (ROS), and therefore systemic oxidative stress. Treatment with metformin would improve such oxidative status.
Identifiants
pubmed: 32640543
pii: ph13070142
doi: 10.3390/ph13070142
pmc: PMC7408130
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerio de Ciencia e Innovación
ID : AGL2013-48121-C3-R
Organisme : Ministerio de Ciencia y Tecnología
ID : AGL2016-79321-C2-1-R
Références
Lancet. 2012 Mar 17;379(9820):992-3
pubmed: 22432152
Nat Rev Endocrinol. 2013 Sep;9(9):537-47
pubmed: 23712250
J Clin Invest. 2001 Oct;108(8):1167-74
pubmed: 11602624
J Nutr. 2008 Feb;138(2):397-402
pubmed: 18203910
N Engl J Med. 1995 Aug 31;333(9):550-4
pubmed: 7623903
Diabetes Care. 2012 Jan;35(1):131-6
pubmed: 22040838
Reprod Domest Anim. 2010 Dec;45(6):1003-7
pubmed: 19473306
FP Essent. 2013 Jul;410:20-4
pubmed: 23869391
ScientificWorldJournal. 2012;2012:510149
pubmed: 22629144
J Clin Endocrinol Metab. 2008 May;93(5):1841-5
pubmed: 18319306
Reprod Domest Anim. 2012 Aug;47 Suppl 4:59-71
pubmed: 22827351
Endocr Metab Immune Disord Drug Targets. 2013 Jun;13(2):143-51
pubmed: 23094796
Diabetes Care. 2011 Nov;34(11):2381-6
pubmed: 21926282
J Clin Endocrinol Metab. 2011 Aug;96(8):E1262-7
pubmed: 21632811
Diabetologia. 2013 Sep;56(9):1898-906
pubmed: 23835523
Ann Surg. 2005 Feb;241(2):334-42
pubmed: 15650645
J Clin Endocrinol Metab. 2005 Oct;90(10):5588-95
pubmed: 16014405
Diab Vasc Dis Res. 2008 Sep;5(3):157-67
pubmed: 18777488
J Pediatr. 2011 Apr;158(4):628-633.e1
pubmed: 21075381
J Pediatr Pharmacol Ther. 2004 Jan;9(1):15-26
pubmed: 23118687
Diabete Metab. 1991 May;17(1 Pt 2):159-63
pubmed: 1936469
Curr Opin Oncol. 2012 Jan;24(1):103-8
pubmed: 22123231
Res Vet Sci. 2012 Aug;93(1):100-2
pubmed: 21917281
J Biol Chem. 2012 Apr 13;287(16):12935-51
pubmed: 22362769
Eur J Pharmacol. 2013 Aug 15;714(1-3):448-55
pubmed: 23845213
J Clin Endocrinol Metab. 2004 Sep;89(9):4331-7
pubmed: 15356029
Nat Rev Endocrinol. 2013 Oct;9(10):607-14
pubmed: 23897171
J Clin Endocrinol Metab. 1995 Dec;80(12):3469-75
pubmed: 8530585
PLoS One. 2013 Oct 24;8(10):e76786
pubmed: 24204674
Biochem Pharmacol. 2012 Dec 15;84(12):1660-70
pubmed: 23041647
PLoS One. 2013 Oct 24;8(10):e78424
pubmed: 24205230
Clin Endocrinol (Oxf). 2007 Sep;67(3):468-71
pubmed: 17608755
J Clin Endocrinol Metab. 2006 Aug;91(8):2888-91
pubmed: 16684823
Diabetes. 2002 Jul;51(7):2074-81
pubmed: 12086935
Yale J Biol Med. 1979 May-Jun;52(3):307-29
pubmed: 380187
Swiss Med Wkly. 2010 Sep 15;140:w13071
pubmed: 20842602
Future Oncol. 2010 Mar;6(3):457-70
pubmed: 20222801
Exp Physiol. 2014 Sep;99(9):1241-52
pubmed: 25085845
J Appl Physiol (1985). 2006 Dec;101(6):1685-92
pubmed: 16902066
BMC Public Health. 2013 May 04;13:440
pubmed: 23642107
Circulation. 2013 Jan 15;127(2):260-7
pubmed: 23212719
J Clin Invest. 2004 Dec;114(12):1752-61
pubmed: 15599400
J Pediatr. 2010 Jan;156(1):98-102.e1
pubmed: 19772969