Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting.
MASTL
actin
cancer
cell cycle
contractility
kinase inhibitor
therapeutic targeting
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
06 07 2020
06 07 2020
Historique:
received:
01
06
2020
revised:
29
06
2020
accepted:
01
07
2020
entrez:
10
7
2020
pubmed:
10
7
2020
medline:
13
4
2021
Statut:
epublish
Résumé
Microtubule-associated serine/threonine kinase-like (MASTL; Greatwall) is a well-characterized kinase, whose catalytic role has been extensively studied in relation to cell-cycle acceleration. Importantly, MASTL has been implicated to play a substantial role in cancer progression and subsequent studies have shown that MASTL is a significant regulator of the cellular actomyosin cytoskeleton. Several kinases have non-catalytic properties, which are essential or even sufficient for their functions. Likewise, MASTL functions have been attributed both to kinase-dependent phosphorylation of downstream substrates, but also to kinase-independent regulation of the actomyosin contractile machinery. In this review, we aimed to highlight the catalytic and non-catalytic roles of MASTL in proliferation, migration, and invasion. Further, we discussed the implications of this dual role for therapeutic design.
Identifiants
pubmed: 32640605
pii: cells9071624
doi: 10.3390/cells9071624
pmc: PMC7407770
pii:
doi:
Substances chimiques
Actins
0
Microtubule-Associated Proteins
0
MASTL protein, human
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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