Fas ligand neutralization attenuates hypertension, endothelin-1, and placental inflammation in an animal model of HELLP syndrome.
Animals
Antibodies, Neutralizing
/ therapeutic use
Disease Models, Animal
Endothelin-1
/ blood
Fas Ligand Protein
/ blood
Female
HELLP Syndrome
/ blood
Immunoglobulin G
Placenta
/ immunology
Pregnancy
Rats
Rats, Sprague-Dawley
Treatment Outcome
Tumor Necrosis Factor-alpha
/ blood
Vascular Endothelial Growth Factor Receptor-1
/ blood
Fas
HELLP syndrome
TNF
hypertension
preeclampsia
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
pubmed:
10
7
2020
medline:
6
10
2020
entrez:
10
7
2020
Statut:
ppublish
Résumé
Neutralization of FasL is linked to suppression of hypertension, placental inflammation, and endothelin system activation in an animal model of hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. During HELLP syndrome the placenta has been reported to serve as the primary source of Fas ligand (FasL), which has an impact on inflammation and hypertension during pregnancy and is dysregulated in women with severe preeclampsia and HELLP syndrome. We hypothesize that neutralization of FasL during pregnancy in an animal model of HELLP syndrome decreases inflammation and placental apoptosis, improves endothelial damage, and improves hypertension. On gestational
Identifiants
pubmed: 32640833
doi: 10.1152/ajpregu.00272.2019
pmc: PMC7473892
doi:
Substances chimiques
Antibodies, Neutralizing
0
Endothelin-1
0
Fas Ligand Protein
0
Immunoglobulin G
0
Tumor Necrosis Factor-alpha
0
Vascular Endothelial Growth Factor Receptor-1
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
R195-R202Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM121334
Pays : United States
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