Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study.
cardiology
lipid disorders
vascular medicine
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
07 07 2020
07 07 2020
Historique:
entrez:
10
7
2020
pubmed:
10
7
2020
medline:
15
5
2021
Statut:
epublish
Résumé
The purpose of this study was to evaluate the relationship between high-density lipoprotein cholesterol (HDL-C) levels and endothelial function in women. Cross-sectional study. 22 university hospitals and affiliated clinics in Japan. 1719 Japanese women aged 17-90 years who were not receiving lipid-lowering therapy. We evaluated flow-mediated vasodilation (FMD) and serum levels of HDL-C. All participants were divided into four groups by HDL-C level: low HDL-C (<40 mg/dL), moderate HDL-C (40-59 mg/dL), high HDL-C (60-79 md/dL) and extremely high HDL-C (≥80 mg/dL). Univariate regression analysis revealed a significant relationship between FMD and HDL-C (r=0.12, p<0.001). FMD values were significantly smaller in the low HDL-C group (5.2%±3.8%) and moderate HDL-C group (5.2%±3.8%) than in the extremely high HDL-C group (6.7%±3.4%) (p=0.024 and p=0.003, respectively), while there was no significant difference in FMD between the high HDL-C group and the extremely high HDL-C group. Multiple logistic regression analysis did not show a significant association between HDL-C levels and FMD. Endothelial function increased in relation to HDL-C levels. However, there was no association of HDL-C levels with endothelial function after adjustment of traditional cardiovascular risk factors in women. UMIN000012950; Results.
Identifiants
pubmed: 32641366
pii: bmjopen-2020-038121
doi: 10.1136/bmjopen-2020-038121
pmc: PMC7342861
doi:
Substances chimiques
Cholesterol, HDL
0
Triglycerides
0
Banques de données
UMIN-CTR
['UMIN000012950']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e038121Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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