Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk.
Carcinoma, Pancreatic Ductal
/ genetics
Case-Control Studies
Celiac Disease
/ genetics
Cholangitis, Sclerosing
/ genetics
Chronic Disease
Colitis, Ulcerative
/ genetics
Crohn Disease
/ genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
/ statistics & numerical data
Humans
Inflammatory Bowel Diseases
/ genetics
Pancreatic Neoplasms
/ genetics
Pancreatitis, Chronic
/ genetics
Pancreatic Neoplasms
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
received:
19
02
2020
revised:
27
04
2020
accepted:
02
07
2020
pubmed:
10
7
2020
medline:
15
1
2021
entrez:
10
7
2020
Statut:
ppublish
Résumé
Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. We examined the association between PDAC and genomic regions (±500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. We analyzed summary statistics from genome-wide association studies data for 8,384 cases and 11,955 controls of European descent from two large consortium studies using the summary data-based adaptive rank truncated product method to examine the overall association of combined genomic regions for each inflammatory disease group. Combined genomic susceptibility regions for ulcerative colitis, Crohn disease, inflammatory bowel disease, and chronic pancreatitis were associated with PDAC at
Identifiants
pubmed: 32641412
pii: 0008-5472.CAN-20-0447
doi: 10.1158/0008-5472.CAN-20-0447
pmc: PMC7861352
mid: NIHMS1610801
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
4004-4013Subventions
Organisme : NCI NIH HHS
ID : U10 CA037429
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA062924
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA222159
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA189974
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA102701
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 CP010193
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA154823
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA050706
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA097075
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA071789
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA247283
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA100967
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA182934
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
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