Murine Leukemia Virus P50 Protein Counteracts APOBEC3 by Blocking Its Packaging.
Alternative Splicing
Animals
Capsid
/ metabolism
Cytidine Deaminase
/ deficiency
Gene Expression Regulation, Viral
Gene Products, gag
/ genetics
HEK293 Cells
Host-Pathogen Interactions
/ genetics
Humans
Leukemia, Experimental
/ genetics
Mice
Mice, Knockout
Moloney murine leukemia virus
/ genetics
NIH 3T3 Cells
Retroviridae Infections
/ genetics
Signal Transduction
Tumor Virus Infections
/ genetics
Virion
/ genetics
Virus Replication
APOBEC3
accessory protein
restriction factor
retrovirus
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
31 08 2020
31 08 2020
Historique:
received:
09
01
2020
accepted:
01
07
2020
pubmed:
10
7
2020
medline:
25
11
2020
entrez:
10
7
2020
Statut:
epublish
Résumé
Apolipoprotein B editing enzyme, catalytic polypeptide 3 (APOBEC3) family members are cytidine deaminases that play important roles in intrinsic responses to retrovirus infection. Complex retroviruses like human immunodeficiency virus type 1 (HIV-1) encode the viral infectivity factor (Vif) protein to counteract APOBEC3 proteins. Vif induces degradation of APOBEC3G and other APOBEC3 proteins and thereby prevents their packaging into virions. It is not known if murine leukemia virus (MLV) encodes a Vif-like protein. Here, we show that the MLV P50 protein, produced from an alternatively spliced
Identifiants
pubmed: 32641479
pii: JVI.00032-20
doi: 10.1128/JVI.00032-20
pmc: PMC7459557
pii:
doi:
Substances chimiques
Gene Products, gag
0
Apobec3 protein, mouse
EC 3.5.4.5
Cytidine Deaminase
EC 3.5.4.5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI085015
Pays : United States
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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