LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication.
Animals
Axons
/ metabolism
Dopaminergic Neurons
/ cytology
Frizzled Receptors
/ metabolism
Gene Knockdown Techniques
Growth Cones
/ metabolism
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
/ genetics
Mice
Models, Biological
Mutation
Neurogenesis
/ genetics
Neurons
/ metabolism
Phosphorylation
Signal Transduction
Spinal Cord
/ cytology
Frizzled3–Vangl2 interaction
LRRK2
Wnt/planar cell polarity
axon guidance
growth cone–growth cone interaction
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
28 07 2020
28 07 2020
Historique:
pubmed:
10
7
2020
medline:
18
9
2020
entrez:
10
7
2020
Statut:
ppublish
Résumé
Axon-axon interactions are essential for axon guidance during nervous system wiring. However, it is unknown whether and how the growth cones communicate with each other while sensing and responding to guidance cues. We found that the Parkinson's disease gene, leucine-rich repeat kinase 2 (
Identifiants
pubmed: 32641508
pii: 1921878117
doi: 10.1073/pnas.1921878117
pmc: PMC7395514
doi:
Substances chimiques
FZD3 protein, human
0
Frizzled Receptors
0
LRRK2 protein, human
EC 2.7.11.1
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
18037-18048Subventions
Organisme : NINDS NIH HHS
ID : P30 NS047101
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS047484
Pays : United States
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: Y.Z. is the founder of VersaPeutics and has equity, compensation, and interim managerial role. The terms of this arrangement have been reviewed and approved by the University of California San Diego in accordance with its conflict of interest policies.
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