Sevoflurane induces neuronal activation and behavioral hyperactivity in young mice.
Anesthesia, Inhalation
/ adverse effects
Anesthetics, Inhalation
/ administration & dosage
Animals
Behavior, Animal
/ drug effects
Disease Models, Animal
Female
Humans
Hypnotics and Sedatives
/ administration & dosage
Male
Mice
Neurons
/ drug effects
Propofol
/ administration & dosage
Psychomotor Agitation
/ diagnosis
Sevoflurane
/ administration & dosage
Somatosensory Cortex
/ cytology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 07 2020
08 07 2020
Historique:
received:
04
12
2019
accepted:
28
05
2020
entrez:
10
7
2020
pubmed:
10
7
2020
medline:
22
12
2020
Statut:
epublish
Résumé
Sevoflurane, a commonly used anesthetic, may cause agitation in patients. However, the mechanism underlying this clinical observation remains largely unknown. We thus assessed the effects of sevoflurane on neuronal activation and behaviors in mice. Ten-day-old mice received 2% sevoflurane, 1% isoflurane, or 6% desflurane for 10 minutes. The behavioral activities were recorded and evaluated at one minute after the loss of righting reflex in the mice, which was about two minutes after the anesthetic administration. The neuronal activation was evaluated by c-Fos expression and calcium imaging at one minute after the anesthetic administration. Propofol, which reduces neuronal activation, was used to determine the cause-and-effect of sevoflurane. We found that sevoflurane caused an increase in neuronal activation in primary somatosensory cortex of young mice and behavioral hyperactivity in the mice at one minute after the loss of righting reflex. Desflurane did not induce behavioral hyperactivity and isoflurane only caused behavioral hyperactivity with borderline significance. Finally, propofol attenuated the sevoflurane-induced increase in neuronal activation and behavioral hyperactivity in young mice. These results demonstrate an unexpected sevoflurane-induced increase in neuronal activation and behavioral hyperactivity in young mice. These findings suggest the potential mechanisms underlying the sevoflurane-induced agitation and will promote future studies to further determine whether anesthetics can induce behavioral hyperactivity via increasing neuronal activation.
Identifiants
pubmed: 32641746
doi: 10.1038/s41598-020-66959-x
pii: 10.1038/s41598-020-66959-x
pmc: PMC7343864
doi:
Substances chimiques
Anesthetics, Inhalation
0
Hypnotics and Sedatives
0
Sevoflurane
38LVP0K73A
Propofol
YI7VU623SF
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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