Population-based surveys of antibodies against SARS-CoV-2 in Southern Brazil.
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral
/ blood
Betacoronavirus
/ immunology
Brazil
/ epidemiology
COVID-19
Child
Child, Preschool
Coronavirus Infections
/ blood
Female
Humans
Immunoglobulin M
/ blood
Infant
Male
Middle Aged
Pandemics
Pneumonia, Viral
/ blood
SARS-CoV-2
Seroepidemiologic Studies
Young Adult
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
30
04
2020
accepted:
24
06
2020
pubmed:
10
7
2020
medline:
28
8
2020
entrez:
10
7
2020
Statut:
ppublish
Résumé
Population-based data on COVID-19 are urgently needed. We report on three rounds of probability sample household surveys in the state of Rio Grande do Sul (Brazil), carried out in nine large municipalities using the Wondfo lateral flow point-of-care test for immunoglobulin M and G antibodies against SARS-CoV-2 (https://en.wondfo.com.cn/product/wondfo-sars-cov-2-antibody-test-lateral-flow-method-2/). Before survey use, the assay underwent four validation studies with pooled estimates of sensitivity (84.8%; 95% confidence interval (CI) = 81.4-87.8%) and specificity (99.0%; 95% CI = 97.8-99.7%). We calculated that the seroprevalence was 0.048% (2/4,151; 95% CI = 0.006-0.174) on 11-13 April (round 1), 0.135% (6/4,460; 95% CI = 0.049-0.293%) on 25-27 April (round 2) and 0.222% (10/4,500; 95% CI = 0.107-0.408) on 9-11 May (round 3), with a significant upward trend over the course of the surveys. Of 37 family members of positive individuals, 17 (35%) were also positive. The epidemic is at an early stage in the state, and there is high compliance with social distancing, unlike in other parts of Brazil. Periodic survey rounds will continue to monitor trends until at least the end of September, and our population-based data will inform decisions on preventive policies and health system preparedness at the state level.
Identifiants
pubmed: 32641783
doi: 10.1038/s41591-020-0992-3
pii: 10.1038/s41591-020-0992-3
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin M
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1196-1199Références
Pearce, N., Vandenbroucke, J. P., VanderWeele, T. J. & Greenland, S. Accurate statistics on COVID-19 are essential for policy guidance and decisions. Am. J. Public Health 110, 949–951 (2020).
doi: 10.2105/AJPH.2020.305708
Barreto, M. L. et al. What is urgent and necessary to inform policies to deal with the COVID-19 pandemic in Brazil? Rev. Bras. Epidemiol. 23, e200032 (2020).
doi: 10.1590/1980-549720200032
Gudbjartsson, D. F. et al. Spread of SARS-CoV-2 in the Icelandic population. N. Engl. J. Med. 382, 2302–2315 (2020).
doi: 10.1056/NEJMoa2006100
Ogris, G. & Hofinger, C. COVID-19 Prevalence (SORA Institute for Social Research and Consulting, 2020).
Nya Resultat från Undersökning av Förekomsten av COVID-19 i Sverige (Public Health Agency of Sweden, 2020).
Estudio ENE-COVID19: Primera Ronda Estudio Nacional de Sero-Epidemiologia de la Infección por SARS-CoV-2 en España. Informe Preliminar 13 Mayo de 2020 (Ministerio de Ciencia e Innovacion and Ministerio de Salud, 2020).
Comitê Técnico do Inquérito Epidemiológico SARS-CoV-2 Avaliação da Prevalência de Marcadores Virológicos e Sorológicos do SARS-CoV-2 na População de Ribeirão Preto: um Inquérito Epidemiológico. Resultados Preliminares (Universidade de São Paulo, Ribeirão Preto, 2020).
Regalado, A. Blood tests show 14% of people are now immune to COVID-19 in one town in Germany. MIT Technology Review (9 April 2020).
Day, M. COVID-19: identifying and isolating asymptomatic people helped eliminate virus in Italian village. Br. Med. J. 368, m1165 (2020).
doi: 10.1136/bmj.m1165
Coronavirus Disease 19, Republic of South Korea (Ministry of Health and Welfare (South Korea), 2020).
Bendavid, E. et al. COVID-19 antibody seroprevalence in Santa Clara County, California. Preprint at medRxiv https://doi.org/10.1101/2020.04.14.20062463 (2020).
USC-LA County Study: Early Results of Antibody Testing Suggest Number of COVID-19 Infections Far Exceeds Number of Confirmed Cases in Los Angeles County (County of Los Angeles Public Health, 2020).
Whitman, J. D. et al. Test performance evaluation of SARS-CoV-2 serological assays. Preprint at medRxiv https://doi.org/10.1101/2020.04.25.20074856 (2020).
Pellanda, L. C. et al. Sensitivity and specificity of a rapid test for assessment of exposure to SARS-CoV-2 in a community-based setting in Brazil. Preprint at medRxiv https://doi.org/10.1101/2020.05.06.20093476 (2020).
Advice on the Use of Point-of-Care Immunodiagnostic Tests for COVID-19 Scientific Brief (WHO, 2020).
“Immunity passports” in the Context of COVID-19 Scientific Brief (WHO, 2020).
Pesquisa Nacional por Amostra de Domicílios: Síntese de Indicadores 2015 (Instituto Brasileiro de Geografia e Estatística, 2016).
Projeções da População (Instituto Brasileiro de Geografia e Estatística, 2019).
Horta, B. L. et al. Cohort profile update: the 1982 Pelotas (Brazil) Birth Cohort Study. Int J. Epidemiol. 44, 441 (2015).
doi: 10.1093/ije/dyv017
Hallal, P. C. et al. Evolução da prevalência de infecção por COVID-19 no Rio Grande do Sul: inquéritos sorológicos seriados. Cien Saude Colet. 25, 2395–2401 (2020).
doi: 10.1590/1413-81232020256.1.09632020
Diggle, P. J. Estimating prevalence using an imperfect test. Epidemiol. Res. Int. 2011, e608719 (2011).
doi: 10.1155/2011/608719
R Core Development Team R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, 2018); https://www.R-project.org/
Lumley, T. Analysis of complex survey samples. J. Stat. Softw. 9, 1–19 (2004).
doi: 10.18637/jss.v009.i08
Lumley, T. survey: Analysis of complex survey samples. R package version 3.35-1 https://CRAN.R-project.org/package=survey (2019).
Viechtbauer, W. Conducting meta‐analyses in R with the metafor package. J. Stat. Softw. 36, 1–48 (2010).
doi: 10.18637/jss.v036.i03