TIMP1 preserves the blood-brain barrier through interacting with CD63/integrin
AJ, adherent junction
BBB, blood–brain barrier
Blood–brain barrier
CD63
CNS, central nervous system
EC, endothelial cells
HBMEC, human brain microvessel endothelial cell
Integrin β1
Junctional proteins
MMP9, matrix metalloproteinase-9
TBI, traumatic brain injury
TIMP1, tissue inhibitors of metalloproteinases-1
TJ, tight junction
Tissue inhibitor of metalloproteinase-1
Journal
Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
25
12
2019
revised:
22
01
2020
accepted:
03
02
2020
entrez:
10
7
2020
pubmed:
10
7
2020
medline:
10
7
2020
Statut:
ppublish
Résumé
Blood-brain barrier (BBB) breakdown and the associated microvascular hyperpermeability are hallmark features of several neurological disorders, including traumatic brain injury (TBI). However, there is no viable therapeutic strategy to rescue BBB function. Tissue inhibitor of metalloproteinase-1 (TIMP1) has been considered to be beneficial for vascular integrity, but the molecular mechanisms underlying the functions of TIMP1 remain elusive. Here, we report that TIMP1 executes a protective role on neuroprotective function
Identifiants
pubmed: 32642407
doi: 10.1016/j.apsb.2020.02.015
pii: S2211-3835(19)31841-6
pmc: PMC7332810
doi:
Types de publication
Journal Article
Langues
eng
Pagination
987-1003Informations de copyright
© 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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