Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake.
Hematological toxicity
Meta-iodobenzylguanidine (MIBG)
Platelets
Selective serotonin reuptake inhibitor (SSRI)
Thrombocytopenia
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
08 Jul 2020
08 Jul 2020
Historique:
received:
02
01
2020
accepted:
25
06
2020
entrez:
10
7
2020
pubmed:
10
7
2020
medline:
10
7
2020
Statut:
epublish
Résumé
The therapeutic use of [ To determine the transport kinetics of SERT for [ SERT performed as a low-affinity transporter of [ Our study demonstrates for the first time that SSRIs selectively inhibit MIBG uptake in platelets without affecting MIBG accumulation in an in vivo neuroblastoma model. The concomitant application of citalopram during [
Sections du résumé
BACKGROUND
BACKGROUND
The therapeutic use of [
METHODS
METHODS
To determine the transport kinetics of SERT for [
RESULTS
RESULTS
SERT performed as a low-affinity transporter of [
CONCLUSION
CONCLUSIONS
Our study demonstrates for the first time that SSRIs selectively inhibit MIBG uptake in platelets without affecting MIBG accumulation in an in vivo neuroblastoma model. The concomitant application of citalopram during [
Identifiants
pubmed: 32642907
doi: 10.1186/s13550-020-00662-w
pii: 10.1186/s13550-020-00662-w
pmc: PMC7343696
doi:
Types de publication
Journal Article
Langues
eng
Pagination
78Subventions
Organisme : Foundation for Pediatric Cancer Research
ID : No 93-011
Organisme : Dutch Cancer Society
ID : NKI 94-084
Organisme : European Community
ID : BMH4-CT98-3297
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