Metabolic Activation of Pirfenidone Mediated by Cytochrome P450s and Sulfotransferases.

Animals Anti-Inflammatory Agents, Non-Steroidal / chemistry Cytochrome P-450 Enzyme System / chemistry Male Mice Microsomes, Liver / drug effects Pyridones / chemistry Random Allocation Rats Rats, Sprague-Dawley Sulfotransferases / chemistry

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
13 08 2020
Historique:
pubmed: 10 7 2020
medline: 26 11 2020
entrez: 10 7 2020
Statut: ppublish

Résumé

Pirfenidone is approved for the treatment of idiopathic pulmonary fibrosis. Idiosyncratic drug reactions, due to clinical application of pirfenidone, have been documented, even along with death cases resulting from acute liver failure. The present study aimed at the investigation of metabolic activation of pirfenidone possibly participating in the reported adverse reactions. Pirfenidone-derived glutathione/

Identifiants

DOI: 10.1021/acs.jmedchem.9b02073 PMID: 32643929
pubmed: 32643929
doi: 10.1021/acs.jmedchem.9b02073
doi:

Substances chimiques

Anti-Inflammatory Agents, Non-Steroidal 0
Pyridones 0
Cytochrome P-450 Enzyme System 9035-51-2
pirfenidone D7NLD2JX7U
Sulfotransferases EC 2.8.2.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8059-8068

Auteurs

Shenzhi Zhou (S)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Wei Li (W)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Min Tian (M)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Na Zhang (N)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Xiaojing Yang (X)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Weiwei Li (W)

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, Guizhou 550025, P. R. China.

Ying Peng (Y)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Jiang Zheng (J)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, Guizhou 550025, P. R. China.
Key Laboratory of Environmental Pollution, Monitoring and Disease Control (J.Z.), Ministry of Education, Guizhou Medical University, Guiyang 550025, P. R. China.
ORCID: 0000-0002-0340-0275

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Metabolic Activation of Pirfenidone Mediated...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antirhumatismaux › Anti-inflammatoires non stéroïdiens › Metabolic Activation of Pirfenidone Mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Metabolic Activation of Pirfenidone Mediated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Metabolic Activation of Pirfenidone Mediated...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Metabolic Activation of Pirfenidone Mediated...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Pyridones › Metabolic Activation of Pirfenidone Mediated...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Répartition aléatoire › Metabolic Activation of Pirfenidone Mediated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Metabolic Activation of Pirfenidone Mediated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Metabolic Activation of Pirfenidone Mediated...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Sulfur group transferases › Sulfotransferases › Metabolic Activation of Pirfenidone Mediated...