Immobilization of Paclitaxel on Hydroxyapatite for Breast Cancer Investigations.

Breast Neoplasms / drug therapy Cell Survival Chitosan Durapatite Female Humans Nanoparticles Paclitaxel / pharmacology

Journal

Langmuir : the ACS journal of surfaces and colloids
ISSN: 1520-5827
Titre abrégé: Langmuir
Pays: United States
ID NLM: 9882736

Informations de publication

Date de publication:
04 08 2020
Historique:
pubmed: 10 7 2020
medline: 22 6 2021
entrez: 10 7 2020
Statut: ppublish

Résumé

A simple method for immobilization of the chemotherapy drug paclitaxel (PTX) on hydroxyapatite nanoparticles (n-HAP) using the biopolymer chitosan as a trapping agent is described focusing on applications involving breast cancer cells. n-HAP with two distinct crystallinity profiles were used: with predominant crystallization along the long axis and with a more homogeneous crystallization in all directions. In the first scenario, the interactions between chitosan and both the OH and PO

Identifiants

DOI: 10.1021/acs.langmuir.0c00868 PMID: 32643936
pubmed: 32643936
doi: 10.1021/acs.langmuir.0c00868
doi:

Substances chimiques

Chitosan 9012-76-4
Durapatite 91D9GV0Z28
Paclitaxel P88XT4IS4D

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8723-8732

Auteurs

Murillo L Martins (ML)

Post-Graduation Program in Industrial and Systems Engineering, Pontifical Catholic University of Goiás, Goiânia 74175-120, Goiás, Brazil.
ORCID: 0000-0002-3883-9114

Thais S Pinto (TS)

Laboratory of Bioassays and Cellular Dynamics (LaBIO), Chemistry and Biochemistry Department, Bioscience Institute of Botucatu (IBB), State University of São Paulo (UNESP), Botucatu 18618-000, São Paulo, Brazil.

Anderson M Gomes (AM)

Laboratory of Bioassays and Cellular Dynamics (LaBIO), Chemistry and Biochemistry Department, Bioscience Institute of Botucatu (IBB), State University of São Paulo (UNESP), Botucatu 18618-000, São Paulo, Brazil.

João P R L L Parra (JPRLL)

Laboratory of Bioassays and Cellular Dynamics (LaBIO), Chemistry and Biochemistry Department, Bioscience Institute of Botucatu (IBB), State University of São Paulo (UNESP), Botucatu 18618-000, São Paulo, Brazil.
ORCID: 0000-0001-7575-2117

Gilberto C Franchi (GC)

Onco-Hematological Child Research Center (CIPOI), Faculty of Medical Sciences, University of Campinas-UNICAMP, Campinas 13083-970, São Paulo, Brazil.

Willian F Zambuzzi (WF)

Laboratory of Bioassays and Cellular Dynamics (LaBIO), Chemistry and Biochemistry Department, Bioscience Institute of Botucatu (IBB), State University of São Paulo (UNESP), Botucatu 18618-000, São Paulo, Brazil.

Cloves G Rodrigues (CG)

Post-Graduation Program in Industrial and Systems Engineering, Pontifical Catholic University of Goiás, Goiânia 74175-120, Goiás, Brazil.
School of Exact Sciences and Computing, Pontifical Catholic University of Goiás, Goiânia 74175-120, Goiás, Brazil.

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Classifications MeSH

questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Immobilization of Paclitaxel on Hydroxyapatite...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Immobilization of Paclitaxel on Hydroxyapatite...
questionsmedicales.fr › Glucides › Polyosides › Chitine › Chitosane › Immobilization of Paclitaxel on Hydroxyapatite...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Phosphates de calcium › Apatites › Hydroxyapatites › Durapatite › Immobilization of Paclitaxel on Hydroxyapatite...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Immobilization of Paclitaxel on Hydroxyapatite...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Immobilization of Paclitaxel on Hydroxyapatite...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Taxoïdes › Paclitaxel › Immobilization of Paclitaxel on Hydroxyapatite...