A structural magnetic resonance imaging study in therapy-naïve transsexual individuals.
FSL
magnetic resonance imaging
subcortical brain structures
transsexuals
Journal
Folia morphologica
ISSN: 1644-3284
Titre abrégé: Folia Morphol (Warsz)
Pays: Poland
ID NLM: 0374620
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
05
2020
accepted:
01
07
2020
revised:
16
06
2020
pubmed:
10
7
2020
medline:
16
10
2021
entrez:
10
7
2020
Statut:
ppublish
Résumé
Transsexuality is explained and defined as a gender-identity disorder, characterised by very strong conviction of belonging to the opposite sex and has been associated with a distinct neuroanatomical pattern. We performed a structural analysis in search of possible differences in grey matter structures based on magnetic resonance imaging scans of the brains of 26 individuals between 19 and 38 years of age. The participants were divided into two groups of 15 controls and 11 transgender individuals. The segmentation of subcortical grey matter was performed using FIRST model a model-based segmentation/registration tool, from FSL software package. The results showed that the volume of the brain region called nucleus accumbens on the left side was significantly smaller in the group of transgender individuals compared to the control. It was the most important parameter which was shown to make distinction between two examined groups. The results also showed decreased volumes of the left thalamus, right hippocampus and right caudate nucleus.
Sections du résumé
BACKGROUND
BACKGROUND
Transsexuality is explained and defined as a gender-identity disorder, characterised by very strong conviction of belonging to the opposite sex and has been associated with a distinct neuroanatomical pattern.
MATERIALS AND METHODS
METHODS
We performed a structural analysis in search of possible differences in grey matter structures based on magnetic resonance imaging scans of the brains of 26 individuals between 19 and 38 years of age. The participants were divided into two groups of 15 controls and 11 transgender individuals. The segmentation of subcortical grey matter was performed using FIRST model a model-based segmentation/registration tool, from FSL software package.
RESULTS
RESULTS
The results showed that the volume of the brain region called nucleus accumbens on the left side was significantly smaller in the group of transgender individuals compared to the control. It was the most important parameter which was shown to make distinction between two examined groups.
CONCLUSIONS
CONCLUSIONS
The results also showed decreased volumes of the left thalamus, right hippocampus and right caudate nucleus.
Identifiants
pubmed: 32644184
pii: VM/OJS/J/69091
doi: 10.5603/FM.a2020.0073
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM