Molecular pathogenesis of the hyaluronic acid capsule of Pasteurella multocida.
Capsule
Molecular mimicry
Pasteurella multocida
Pathogenic mechanism
Virulence
Journal
Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
22
02
2020
revised:
02
07
2020
accepted:
02
07
2020
pubmed:
10
7
2020
medline:
22
6
2021
entrez:
10
7
2020
Statut:
ppublish
Résumé
Pasteurella multocida possesses a viscous capsule polysaccharide on the cell surface, which is a critical structural component and virulence factor. Capsular polysaccharides are structurally similar to vertebrate glycosaminoglycans, providing an immunological mechanism for bacterial molecular mimicry, resistance to phagocytosis, and immune evasion during the infection process. Based on the capsular antigen, P. multocida is divided into A, B, D, E, and F five serogroups. Previously, we systematically reported the biosynthesis and regulation mechanisms of the P. multocida capsule. In this paper, we take serogroup A capsular polysaccharide as the representative, systematically illuminating the P. multocida capsular virulence and epidemiology, molecular camouflage, adhesion and colonization, anti-phagocytosis, anti-complement system, cell invasion and signal transduction mechanism, to provide a theoretical basis for the research of molecular pathogenic mechanism of P. multocida capsule and the development of polysaccharides vaccine.
Identifiants
pubmed: 32645423
pii: S0882-4010(20)30746-4
doi: 10.1016/j.micpath.2020.104380
pii:
doi:
Substances chimiques
Virulence Factors
0
Hyaluronic Acid
9004-61-9
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104380Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.