In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations.
Carbopol
Eudragit
GRDDS
alginate
cellulose
floating
gastroretentive
gums
low-density
polysaccharides
raft systems
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
07 Jul 2020
07 Jul 2020
Historique:
received:
12
05
2020
revised:
30
06
2020
accepted:
03
07
2020
entrez:
11
7
2020
pubmed:
11
7
2020
medline:
11
7
2020
Statut:
epublish
Résumé
The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it difficult to achieve therapeutic levels in the organism; moreover, some drugs must act locally due to a gastric pathology, but the time they remain in the stomach is short. The use of formulations capable of improving all these parameters, as well as increasing the resident time in the stomach, has been the target of numerous research works, with low-density systems being the most promising and widely explored, however, there is further scope to improve these systems. There are a vast variety of polymeric materials used in low-density gastroretentive systems and a number of methods to improve the bioavailability of the drugs. This works aims to expedite the development of breakthrough approaches by providing an in-depth understanding of the polymeric materials currently used, both natural and synthetic, their properties, advantages, and drawbacks.
Identifiants
pubmed: 32645909
pii: pharmaceutics12070636
doi: 10.3390/pharmaceutics12070636
pmc: PMC7408198
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : MAT2012-38044C03-01
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : MAT2016-77345-C3-2-P
Organisme : Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía
ID : P12-FPM-1553
Références
Int J Biol Macromol. 2018 May;111:62-69
pubmed: 29292143
ACS Appl Mater Interfaces. 2016 Feb 10;8(5):3182-92
pubmed: 26760672
Eur J Pharm Sci. 2014 Jul 16;58:34-43
pubmed: 24704154
Int J Pharm. 2015;486(1-2):297-305
pubmed: 25843757
Adv Mater. 2018 Dec;30(49):e1802309
pubmed: 30133009
Adv Drug Deliv Rev. 2001 Jun 11;48(2-3):139-57
pubmed: 11369079
Biotechnol J. 2010 Jan;5(1):85-98
pubmed: 19902461
Eur J Pharm Biopharm. 2016 Jan;98:108-21
pubmed: 26643801
Adv Drug Deliv Rev. 2010 Jan 31;62(1):83-99
pubmed: 19799949
Drug Dev Ind Pharm. 2014 Mar;40(3):398-408
pubmed: 23418961
Drug Des Devel Ther. 2015 Mar 31;9:1843-57
pubmed: 25848220
Int J Pharm. 2006 Jun 19;316(1-2):86-92
pubmed: 16567072
Curr Drug Deliv. 2012 Sep;9(5):437-51
pubmed: 22920574
PLoS One. 2019 May 15;14(5):e0216875
pubmed: 31091273
J Control Release. 2013 Jun 10;168(2):151-65
pubmed: 23500062
Eur J Pharm Biopharm. 2015 Aug;94:513-20
pubmed: 26143367
Drug Des Devel Ther. 2017 Apr 03;11:1081-1093
pubmed: 28435220
Pharmaceutics. 2020 Jan 17;12(1):
pubmed: 31963484
Int J Pharm. 2008 Oct 1;362(1-2):37-43
pubmed: 18588962
Adv Drug Deliv Rev. 2005 Nov 3;57(11):1595-639
pubmed: 16198021
PLoS One. 2015 Jun 02;10(6):e0126874
pubmed: 26035710
J Bacteriol. 1993 May;175(9):2490-500
pubmed: 7683019
Int J Pharm. 2007 May 24;336(2):329-37
pubmed: 17223290
Drug Deliv. 2016 Oct;23(8):2736-2746
pubmed: 26165421
Int J Pharm Investig. 2011 Oct;1(4):247-54
pubmed: 23071951
J Pharm Sci. 2019 Aug;108(8):2552-2560
pubmed: 30878514
Carbohydr Polym. 2020 Oct 15;246:116519
pubmed: 32747229
Int J Pharm. 2013 Dec 5;457(2):428-36
pubmed: 23428882
Int J Pharm. 2017 Mar 15;519(1-2):186-197
pubmed: 28017768
Eur J Pharm Biopharm. 2010 Feb;74(2):332-9
pubmed: 19932750
Int J Pharm. 2014 May 15;466(1-2):266-75
pubmed: 24631309
Eur J Pharm Biopharm. 2014 Nov;88(3):778-86
pubmed: 25086221
Int J Pharm. 2016 Aug 20;510(1):144-58
pubmed: 27173823
Chin J Nat Med. 2018 Apr;16(4):293-301
pubmed: 29703329
Int J Pharm. 2015 Jul 15;489(1-2):210-7
pubmed: 25956047
J Pharm Pharmacol. 1993 Jan;45(1):21-4
pubmed: 8094440
J Pharm Sci. 2011 Jan;100(1):150-63
pubmed: 20572054
Eur J Pharm Biopharm. 2015 Jan;89:82-92
pubmed: 25448073
Int J Pharm. 2004 May 4;275(1-2):97-107
pubmed: 15081141
Eur J Pharm Biopharm. 2019 Apr;137:196-208
pubmed: 30826475
Int J Pharm. 2007 Apr 4;334(1-2):35-41
pubmed: 17097841
J Drug Target. 2015 Feb;23(2):109-24
pubmed: 25268275
Int J Pharm. 2004 Apr 15;274(1-2):233-43
pubmed: 15072799
Int J Pharm. 2005 Apr 27;294(1-2):137-47
pubmed: 15814238
AAPS PharmSciTech. 2005 Dec 12;6(4):E634-40
pubmed: 16408865
Drug Dev Ind Pharm. 2013 Jun;39(6):880-8
pubmed: 22901056
Int J Pharm. 2008 Feb 4;348(1-2):169-74
pubmed: 17706903
AAPS PharmSciTech. 2009;10(3):864-71
pubmed: 19568939
J Control Release. 2010 Oct 1;147(1):2-16
pubmed: 20493217
Pharm Res. 2018 Apr 23;35(6):125
pubmed: 29687226
Eur J Pharm Biopharm. 2007 Aug;67(1):196-201
pubmed: 17270409
Drug Deliv. 2002 Oct-Dec;9(4):223-31
pubmed: 12511200
Eur J Pharm Sci. 2010 Jan 31;39(1-3):82-9
pubmed: 19903527
Int J Pharm. 2002 Jul 25;241(2):279-92
pubmed: 12100855
Drug Deliv. 2016;23(2):378-94
pubmed: 25026414
J Microencapsul. 1998 Nov-Dec;15(6):725-37
pubmed: 9818950
Int J Pharm. 2014 Dec 10;476(1-2):223-31
pubmed: 25283698
Drug Deliv. 2011 May;18(4):255-64
pubmed: 21110695
Pharmaceutics. 2019 Apr 20;11(4):
pubmed: 31010054
Int J Pharm. 2018 Jan 15;535(1-2):325-332
pubmed: 29051121
Indian J Pharm Sci. 2010 Sep;72(5):571-5
pubmed: 21694987
J Microencapsul. 2000 Jan-Feb;17(1):57-67
pubmed: 10670940
Drug Deliv. 2003 Jul-Sep;10(3):151-60
pubmed: 12944135
Pharmaceutics. 2020 Jan 08;12(1):
pubmed: 31936212
Int J Pharm. 2007 Apr 20;335(1-2):114-122
pubmed: 17141986
J Control Release. 2007 Jun 4;119(2):207-14
pubmed: 17412443
Eur J Pharm Biopharm. 2007 Jan;65(1):85-93
pubmed: 16971097
Int J Pharm. 2018 Jul 10;545(1-2):37-44
pubmed: 29649518
J Control Release. 1998 Oct 30;55(1):3-12
pubmed: 9795000
Pharmaceutics. 2019 Jun 10;11(6):
pubmed: 31185692
J Control Release. 2001 Feb 23;70(3):341-51
pubmed: 11182204
Int J Pharm. 2012 Jan 17;422(1-2):211-9
pubmed: 22093955
J Control Release. 2005 Oct 3;107(2):300-9
pubmed: 16095748
Int J Biol Macromol. 2014 Jun;67:463-77
pubmed: 24699418
Molecules. 2020 May 16;25(10):
pubmed: 32429452
Pharm Dev Technol. 2018 Feb;23(2):183-197
pubmed: 28985687
Int J Pharm. 2020 Feb 25;576:118989
pubmed: 31931076
Drug Deliv. 2018 Nov;25(1):1161-1174
pubmed: 29792353
Sci Rep. 2017 Jun 6;7(1):2829
pubmed: 28588251
AAPS PharmSciTech. 2006;7(4):95
pubmed: 17285751
Sci Pharm. 2010;78(4):927-39
pubmed: 21179326
J Control Release. 2006 Aug 10;114(1):1-14
pubmed: 16828914
Carbohydr Polym. 2015 Apr 20;120:74-84
pubmed: 25662690
Adv Drug Deliv Rev. 1998 May 4;31(3):267-285
pubmed: 10837629
Int J Pharm. 2019 Jul 20;566:520-531
pubmed: 31185262
Pharmaceutics. 2018 Sep 17;10(3):
pubmed: 30227678
Mol Pharm. 2014 Oct 6;11(10):3471-83
pubmed: 25105340
AAPS PharmSciTech. 2007 Jun 22;8(2):Article 48
pubmed: 17625805
Int J Biol Macromol. 2016 Aug;89:622-31
pubmed: 27177460
J Control Release. 2003 Jun 24;90(2):143-62
pubmed: 12810298
Drug Deliv. 2011 Feb;18(2):97-110
pubmed: 20958237
Pharm Res. 2002 May;19(5):602-8
pubmed: 12069161
Drug Deliv Transl Res. 2018 Dec;8(6):1670-1678
pubmed: 29127610
Drug Dev Ind Pharm. 2004 Apr;30(4):405-12
pubmed: 15132183
Drug Des Devel Ther. 2015 Apr 13;9:2159-69
pubmed: 25926722
J Microencapsul. 2001 Jan-Feb;18(1):65-75
pubmed: 11201342
Int J Pharm. 2011 Feb 14;404(1-2):169-75
pubmed: 21095225
AAPS PharmSciTech. 2001 Nov 26;2(4):24
pubmed: 14727861
Eur J Pharm Biopharm. 2005 Sep;61(1-2):56-68
pubmed: 15893919
Expert Opin Drug Deliv. 2011 Aug;8(8):1009-23
pubmed: 21564000
Int J Pharm. 2018 Oct 25;550(1-2):160-169
pubmed: 30138708