Ten-Year Research Update Review: Antiviral Activities from Marine Organisms.
antiviral
marine natural products
marine organisms
viruses
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
07 07 2020
07 07 2020
Historique:
received:
12
06
2020
revised:
25
06
2020
accepted:
28
06
2020
entrez:
11
7
2020
pubmed:
11
7
2020
medline:
25
7
2020
Statut:
epublish
Résumé
Oceans cover more than 70 percent of the surface of our planet and are characterized by huge taxonomic and chemical diversity of marine organisms. Several studies have shown that marine organisms produce a variety of compounds, derived from primary or secondary metabolism, which may have antiviral activities. In particular, certain marine metabolites are active towards a plethora of viruses. Multiple mechanisms of action have been found, as well as different targets. This review gives an overview of the marine-derived compounds discovered in the last 10 years. Even if marine organisms produce a wide variety of different compounds, there is only one compound available on the market, Ara-A, and only another one is in phase I clinical trials, named Griffithsin. The recent pandemic emergency caused by SARS-CoV-2, also known as COVID-19, highlights the need to further invest in this field, in order to shed light on marine compound potentiality and discover new drugs from the sea.
Identifiants
pubmed: 32645994
pii: biom10071007
doi: 10.3390/biom10071007
pmc: PMC7407529
pii:
doi:
Substances chimiques
Antiviral Agents
0
Biological Products
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Progetto POR Campania
ID : PG/2018/0494374
Pays : International
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