Oral Administration of Sodium Nitrate to Metabolic Syndrome Patients Attenuates Mild Inflammatory and Oxidative Responses to Acute Exercise.
exercise
inflammation
metabolic syndrome
nitrate
oxidative stress
supplementation
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
07 Jul 2020
07 Jul 2020
Historique:
received:
22
05
2020
revised:
03
07
2020
accepted:
04
07
2020
entrez:
11
7
2020
pubmed:
11
7
2020
medline:
11
7
2020
Statut:
epublish
Résumé
The beneficial effects of exercise for the treatment and prevention of metabolic syndrome pathologies have been related to its anti-inflammatory and antioxidant effects. Dietary nitrate supplementation is an emerging treatment strategy to alleviate the symptoms of metabolic syndrome affections and to improve vascular function. In this double-blind crossover trial, metabolic syndrome patients performed two exercise tests for 30 min at 60-70% maximal heart rate after the intake of a placebo or a nitrate-enriched beverage. Acute exercise increased the plasma concentration of TNFα, intercellular adhesion molecule ICAM1, PGE1, PGE2 and the newly detected 16-hydroxypalmitic acid (16-HPAL) in metabolic syndrome patients. The cytokine and oxylipin production by peripheral blood mononuclear cells (PBMCs) and neutrophils could be responsible for the plasma concentrations of TNFα and IL6, but not for the plasma concentration of oxylipins nor its post-exercise increase. The intake of sodium nitrate 30 min before exercise increased the concentration of nitrate and nitrite in the oral cavity and plasma and reduced the oxygen cost of exercise. Additionally, nitrate intake prevented the enhancing effects of acute exercise on the plasma concentration of TNFα, ICAM1, PGE1, PGE2 and 16-HPAL, while reducing the capabilities of PBMCs and neutrophils to produce oxylipins.
Identifiants
pubmed: 32646062
pii: antiox9070596
doi: 10.3390/antiox9070596
pmc: PMC7402183
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : 11/01791
Organisme : Instituto de Salud Carlos III
ID : 14/00636
Organisme : Instituto de Salud Carlos III
ID : RD06/0045/1004
Organisme : Instituto de Salud Carlos III
ID : CB12/03/30038
Organisme : Govern de les Illes Balears
ID : AAEE26/2017
Organisme : Health Research Institute of the Balearic Islands (IdISBa)
ID : PRI19/10
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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