Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases.

Animals Cell Communication / drug effects Cell Death Cell-Derived Microparticles / metabolism Cellular Microenvironment Disease Susceptibility / etiology Humans Inflammasomes / metabolism Interleukin-1beta / metabolism NLR Family, Pyrin Domain-Containing 3 Protein / metabolism Pyroptosis Signal Transduction / drug effects
NLRP3 atherosclerosis inflammasome necroptosis neuroinflammation pyroptosis

Journal

Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035

Informations de publication

Date de publication:
11 2020
Historique:
received: 18 02 2020
revised: 02 06 2020
accepted: 04 06 2020
pubmed: 11 7 2020
medline: 16 10 2021
entrez: 11 7 2020
Statut: ppublish

Résumé

The accumulation of cellular and environmental microparticles has been linked to many diseases associated with tissue inflammation. These particulate-driven diseases include joint, lung, kidney, cardiovascular, and neurodegenerative disorders. Recently a conserved proinflammatory inflammasome signaling pathway elicited by such microparticles has become apparent. Here, we review disease-promoting microparticles and the mechanisms by which they trigger activation of the inflammasome complexes responsible for generating bioactive interleukin-1β (IL-1β) and inducing cell death. We highlight how microparticle-induced inflammasome and cell death responses diverge from canonical inflammasome activators, and discuss the preclinical and clinical targeting of inflammasomes to treat microparticle-driven diseases.

Identifiants

DOI: 10.1016/j.molmed.2020.06.005 PMID: 32646646
pubmed: 32646646
pii: S1471-4914(20)30156-8
doi: 10.1016/j.molmed.2020.06.005
pii:
doi:

Substances chimiques

IL1B protein, human 0
Inflammasomes 0
Interleukin-1beta 0
NLR Family, Pyrin Domain-Containing 3 Protein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1003-1020

Informations de copyright

Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.

Auteurs

Maryam Rashidi (M)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: rashidi@wehi.edu.au.

Ian P Wicks (IP)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.

James E Vince (JE)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: vince@wehi.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Inflammasomes and Cell Death: Common Pathways...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Communication cellulaire › Inflammasomes and Cell Death: Common Pathways...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Inflammasomes and Cell Death: Common Pathways...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Microparticules membranaires › Inflammasomes and Cell Death: Common Pathways...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Inflammasomes and Cell Death: Common Pathways...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Inflammasomes and Cell Death: Common Pathways...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inflammasomes and Cell Death: Common Pathways...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Inflammasomes and Cell Death: Common Pathways...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Monokines › Interleukine-1 › Interleukine-1 bêta › Inflammasomes and Cell Death: Common Pathways...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protéines NLR › Protéine-3 de la famille des NLR contenant un domaine pyrine › Inflammasomes and Cell Death: Common Pathways...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Pyroptose › Inflammasomes and Cell Death: Common Pathways...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Inflammasomes and Cell Death: Common Pathways...