A Prospective, Cross Sectional Study of PNH Clone in MDS Patients Using High Sensitivity Flowcytometry: A Single Center Experience.
Hemolysis
High sensitivity PNH assay
Myelodysplastic syndrome
PNH clone
Paroxysmal nocturnal hemoglobinuria (PNH)
Journal
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
ISSN: 0971-4502
Titre abrégé: Indian J Hematol Blood Transfus
Pays: India
ID NLM: 9425818
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
07
07
2019
accepted:
14
10
2019
entrez:
11
7
2020
pubmed:
11
7
2020
medline:
11
7
2020
Statut:
ppublish
Résumé
Subclinical PNH can be present in patients with bone marrow failure like aplastic anemia and myelodysplastic syndrome (MDS). Such clone may have prognostic and therapeutic implications. In literature around 1-10% MDS cases have shown a PNH clone, however, data from India is relatively scarce. A high sensitivity PNH assay was employed using a single tube combination of FLAER, CD157, CD64, CD15 and CD45 antibodies in adult patients of MDS at presentation. A clone size of > 0.01% was taken as significant. A total of 30 patients were included. PNH clone was present in 30% cases. Correlation done between PNH clone size and LDH values showed moderately positive correlation (r = 0.735,
Identifiants
pubmed: 32647427
doi: 10.1007/s12288-019-01219-1
pii: 1219
pmc: PMC7326846
doi:
Types de publication
Journal Article
Langues
eng
Pagination
519-525Informations de copyright
© Indian Society of Hematology and Blood Transfusion 2019.
Déclaration de conflit d'intérêts
Conflict of interestThe authors have declared no conflict of interest.
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