Hematopoietic Stem Cell Transplantation for Fanconi Anemia: A Single Center Experience from India.
Fanconi anemia
HSCT
Matched sibling donor
Journal
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
ISSN: 0971-4502
Titre abrégé: Indian J Hematol Blood Transfus
Pays: India
ID NLM: 9425818
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
16
09
2019
accepted:
14
01
2020
entrez:
11
7
2020
pubmed:
11
7
2020
medline:
11
7
2020
Statut:
ppublish
Résumé
Hematopoietic stem cell transplantation (HSCT) is the only treatment option for the hematological manifestations of Fanconi anemia (FA). Fludarabine based reduced intensity conditioning regimens have helped in improving outcomes significantly in FA patients. We retrospectively analyzed the outcomes of FA patients who underwent allogeneic HSCT at BLK Superspeciality Hospital, New Delhi from June 2011 to September 2019. Twenty FA patients underwent 23 transplants at our center. Overall survival and disease free survival were 65% and 50%, respectively at a median of 23 months. Overall mortality was 30%. HSCT for FA is a feasible option even in developing countries although children present late to transplant centers after multiple transfusions and infections.
Identifiants
pubmed: 32647434
doi: 10.1007/s12288-020-01254-3
pii: 1254
pmc: PMC7326841
doi:
Types de publication
Journal Article
Langues
eng
Pagination
565-568Informations de copyright
© Indian Society of Hematology and Blood Transfusion 2020.
Déclaration de conflit d'intérêts
Conflict of interestAll authors declare that they have no conflict of interest.
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