Tumor immune microenvironment and mutational analysis of tracheal adenoid cystic carcinoma.

CD8+ T cell PD-L1 T cell receptor Tracheal adenoid cystic carcinoma (TACC) immune checkpoint inhibitors whole-exome sequencing (WES)

Journal

Annals of translational medicine
ISSN: 2305-5839
Titre abrégé: Ann Transl Med
Pays: China
ID NLM: 101617978

Informations de publication

Date de publication:
Jun 2020
Historique:
entrez: 11 7 2020
pubmed: 11 7 2020
medline: 11 7 2020
Statut: ppublish

Résumé

Tracheal adenoid cystic carcinoma (TACC) is the second most common type of cancer in bronchial tumors with poor prognosis. Studies on the genomic profiles and tumor immune microenvironment (TIME) of TACC are still relatively rare. Here, we performed whole-exome sequencing (WES), T cell repertoire (TCR) sequencing, and immunohistochemistry (IHC) on the resected tumors and matched peripheral blood leukocytes (PBLs) samples from 25 TACCs collected from April-2010 to Mar-2019. WES results revealed that In summary, despite the existence of one patient with MSI-H and chromosome instability, TACC was characterized by a lack of common drivers of lung cancer, negative PD-L1 expression, and low CD3+ and CD8+ T cell infiltration.

Sections du résumé

BACKGROUND BACKGROUND
Tracheal adenoid cystic carcinoma (TACC) is the second most common type of cancer in bronchial tumors with poor prognosis. Studies on the genomic profiles and tumor immune microenvironment (TIME) of TACC are still relatively rare.
METHODS METHODS
Here, we performed whole-exome sequencing (WES), T cell repertoire (TCR) sequencing, and immunohistochemistry (IHC) on the resected tumors and matched peripheral blood leukocytes (PBLs) samples from 25 TACCs collected from April-2010 to Mar-2019.
RESULTS RESULTS
WES results revealed that
CONCLUSIONS CONCLUSIONS
In summary, despite the existence of one patient with MSI-H and chromosome instability, TACC was characterized by a lack of common drivers of lung cancer, negative PD-L1 expression, and low CD3+ and CD8+ T cell infiltration.

Identifiants

DOI: 10.21037/atm-20-3433 PMID: 32647675 PMC: PMC7333116
pubmed: 32647675
doi: 10.21037/atm-20-3433
pii: atm-08-12-750
pmc: PMC7333116
doi:

Types de publication

Journal Article

Langues

eng

Pagination

750

Informations de copyright

2020 Annals of Translational Medicine. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-3433). The authors have no conflicts of interest to declare.

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Auteurs

Fei Wang (F)

State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Xiaohong Xie (X)

State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Mengmeng Song (M)

Geneplus-Beijing, Beijing, China.

Liyan Ji (L)

Geneplus-Beijing, Beijing, China.

Ming Liu (M)

State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Pansong Li (P)

Geneplus-Beijing, Beijing, China.

Yanfang Guan (Y)

Geneplus-Beijing, Beijing, China.

Xinqing Lin (X)

State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Yinyin Qin (Y)

State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Zhanhong Xie (Z)

State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Jiexia Zhang (J)

State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Ming Ouyang (M)

State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Yingying Gu (Y)

State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Haiyi Deng (H)

State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Xuefeng Xia (X)

Geneplus-Beijing, Beijing, China.

Yi Xin (Y)

Geneplus-Beijing, Beijing, China.

Chengzhi Zhou (C)

State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Classifications MeSH