Subjective cognitive and non-cognitive complaints and brain MRI biomarkers in the MEMENTO cohort.
magnetic resonance imaging
multi‐center cohort
preclinical AD
subjective health complaints
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
02
2020
revised:
23
05
2020
accepted:
26
05
2020
entrez:
11
7
2020
pubmed:
11
7
2020
medline:
11
7
2020
Statut:
epublish
Résumé
Subjective cognitive complaints may be a signature of preclinical stage Alzheimer's disease. However, the link between subjective cognitive and non-cognitive complaints and brain alterations remains unclear. The relationship between cognitive and non-cognitive complaints and brain biomarkers, measured by structural magnetic resonance imaging, was investigated in 2056 participants of the MEMENTO cohort of outpatients, who were dementia-free at baseline. We assessed whether the cognitive status at inclusion or the presence of the apolipoprotein E gene variant ( Smaller hippocampal volume was associated with higher memory complaints and discomfort in daily life. In The intensity of subjective complaints in not only memory but discomfort in daily life was associated with brain degeneration markers. The presence of
Identifiants
pubmed: 32647745
doi: 10.1002/dad2.12051
pii: DAD212051
pmc: PMC7335902
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12051Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
PLoS One. 2016 May 04;11(5):e0154530
pubmed: 27144832
Behav Brain Res. 2017 Mar 30;322(Pt A):100-109
pubmed: 28108320
Am J Geriatr Psychiatry. 2015 May;23(5):446-55
pubmed: 25204687
Int J Geriatr Psychiatry. 2000 Nov;15(11):983-91
pubmed: 11113976
Acta Psychiatr Scand. 2014 Dec;130(6):439-51
pubmed: 25219393
Int J Geriatr Psychiatry. 2016 Feb;31(2):153-60
pubmed: 26011017
Neuroimage. 2010 Dec;53(4):1244-55
pubmed: 20600995
Lancet Neurol. 2011 Mar;10(3):241-52
pubmed: 21349439
Health Policy. 1991 Jun;18(1):37-48
pubmed: 10112300
Neurobiol Aging. 2018 Nov;71:81-90
pubmed: 30107289
Alzheimers Dement (Amst). 2015 Mar 1;1(1):33-40
pubmed: 25938132
Int J Geriatr Psychiatry. 2020 May;35(5):581-588
pubmed: 32011757
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
Alzheimers Dement (N Y). 2018 May 22;4:224-233
pubmed: 29955665
Dement Geriatr Cogn Disord. 2007;24(3):177-84
pubmed: 17641528
Mol Neurobiol. 2016 Sep;53(7):4539-47
pubmed: 26298664
Dement Geriatr Cogn Disord. 2010;29(1):75-81
pubmed: 20110703
Alzheimers Dement. 2014 Nov;10(6):844-52
pubmed: 24798886
J Alzheimers Dis. 2015 Sep 24;48 Suppl 1:S141-50
pubmed: 26402076
J Intern Med. 2004 Sep;256(3):183-94
pubmed: 15324362
Alzheimers Dement. 2018 Jun;14(6):734-742
pubmed: 29352855
J Geriatr Psychiatry Neurol. 2014 Sep;27(3):181-7
pubmed: 24614203
J Int Neuropsychol Soc. 2014 Sep;20(8):836-47
pubmed: 25156329
Brain Connect. 2013;3(4):353-62
pubmed: 23627661
Nat Rev Neurol. 2010 Feb;6(2):67-77
pubmed: 20139996
Psychol Med. 2011 Sep;41(9):1997-2006
pubmed: 21284913
Alzheimers Dement. 2014 May;10(3):319-27
pubmed: 23871264
Neuroimage. 2009 Jul 1;46(3):749-61
pubmed: 19236922
Curr Opin Neurol. 2010 Aug;23(4):359-67
pubmed: 20489617
Alzheimers Res Ther. 2017 Aug 29;9(1):67
pubmed: 28851447
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
J Neuroimaging. 2016 Jan-Feb;26(1):144-9
pubmed: 25678236
J Alzheimers Dis. 2015 Sep 24;48 Suppl 1:S63-86
pubmed: 26402085
Neurobiol Aging. 2006 Dec;27(12):1751-6
pubmed: 16309795
J Alzheimers Dis. 2017;57(2):625-632
pubmed: 28269773
Alzheimers Dement. 2017 Feb;13(2):186-195
pubmed: 27702619
Neurology. 2004 Feb 24;62(4):591-600
pubmed: 14981176
Physiol Rev. 2007 Jul;87(3):873-904
pubmed: 17615391
J Alzheimers Dis. 2015;45(1):139-46
pubmed: 25471190
Int Psychogeriatr. 2010 Sep;22(6):984-94
pubmed: 20594384