Specificity and regulation of phosphotyrosine signaling through SH2 domains.
Binding specificity
Phosphotyrosine
SH2 domain
pY signalling
Journal
Journal of structural biology: X
ISSN: 2590-1524
Titre abrégé: J Struct Biol X
Pays: United States
ID NLM: 101761384
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
04
2020
revised:
14
05
2020
accepted:
15
05
2020
entrez:
11
7
2020
pubmed:
11
7
2020
medline:
11
7
2020
Statut:
epublish
Résumé
Phosphotyrosine (pY) signaling is instrumental to numerous cellular processes. pY recognition occurs through specialized protein modules, among which the Src-homology 2 (SH2) domain is the most common. SH2 domains are small protein modules with an invariant fold, and are present in more than a hundred proteins with different function. Here we ask the question of how such a structurally conserved, small protein domain can recognize distinct phosphopeptides with the breath of binding affinity, specificity and kinetic parameters necessary for proper control of pY-dependent signaling and rapid cellular response. We review the current knowledge on structure, thermodynamics and kinetics of SH2-phosphopeptide complexes and conclude that selective phosphopeptide recognition is governed by both structure and dynamics of the SH2 domain, as well as by the kinetics of the binding events. Further studies on the thermodynamic and kinetic properties of SH2-phosphopeptide complexes, beyond their structure, are required to understand signaling regulation.
Identifiants
pubmed: 32647828
doi: 10.1016/j.yjsbx.2020.100026
pii: S2590-1524(20)30008-8
pii: 100026
pmc: PMC7337045
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100026Informations de copyright
© 2020 Published by Elsevier Inc.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Biochemistry. 1993 Apr 6;32(13):3197-202
pubmed: 8384875
Mol Cell Proteomics. 2008 Apr;7(4):768-84
pubmed: 17956856
Nat Struct Biol. 1996 Apr;3(4):364-74
pubmed: 8599763
Biochemistry. 1994 May 17;33(19):5984-6003
pubmed: 7514039
Curr Opin Cell Biol. 2009 Apr;21(2):140-6
pubmed: 19269802
Biochemistry. 2000 Aug 22;39(33):10072-81
pubmed: 10955995
Cell. 2004 Jan 23;116(2):191-203
pubmed: 14744431
EMBO J. 1996 Jul 15;15(14):3579-89
pubmed: 8670861
Mol Cell Biol. 1993 Jun;13(6):3567-76
pubmed: 8388538
Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18013-8
pubmed: 17991782
Biochemistry. 1996 Dec 3;35(48):15570-81
pubmed: 8952511
Adv Protein Chem. 2002;61:161-210
pubmed: 12461824
Biochemistry. 1995 Sep 12;34(36):11353-62
pubmed: 7547863
EMBO J. 2002 Feb 1;21(3):314-23
pubmed: 11823424
Cell. 2005 Apr 22;121(2):271-80
pubmed: 15851033
Mol Cell Biol. 1986 Dec;6(12):4396-408
pubmed: 3025655
J Hum Genet. 2005;50(4):192-202
pubmed: 15834506
Methods Enzymol. 2011;488:147-83
pubmed: 21195228
Mol Cell Proteomics. 2019 Feb;18(2):372-382
pubmed: 30482845
Protein Sci. 1994 Jul;3(7):1020-30
pubmed: 7522724
Biochemistry. 2005 Sep 13;44(36):12196-202
pubmed: 16142918
Nature. 2008 Mar 13;452(7184):181-6
pubmed: 18337815
Biochemistry. 1998 Mar 3;37(9):2741-7
pubmed: 9485424
Cell. 2010 Jun 25;141(7):1117-34
pubmed: 20602996
Oncogene. 2004 Oct 18;23(48):7918-27
pubmed: 15489910
Biochemistry. 1996 Jan 16;35(2):361-8
pubmed: 8555205
Cell. 2003 Mar 21;112(6):845-57
pubmed: 12654250
Mol Biol Evol. 2004 May;21(5):828-40
pubmed: 14963097
Nature. 1993 Mar 4;362(6415):87-91
pubmed: 7680435
Protein Sci. 1997 Sep;6(9):1910-9
pubmed: 9300491
Mol Cell. 1999 Oct;4(4):555-61
pubmed: 10549287
Curr Opin Cell Biol. 2001 Apr;13(2):131-8
pubmed: 11248545
Biochemistry. 2011 Sep 6;50(35):7637-46
pubmed: 21800896
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8524-9
pubmed: 12084912
Sci Signal. 2012 Sep 25;5(243):ra68
pubmed: 23012655
Science. 1995 May 26;268(5214):1177-9
pubmed: 7539155
Front Mol Biosci. 2015 Oct 13;2:56
pubmed: 26528483
Mol Cell Biol. 1993 Mar;13(3):1449-55
pubmed: 7680095
Annu Rev Genomics Hum Genet. 2005;6:45-68
pubmed: 16124853
J Mol Biol. 1999 Nov 5;293(4):971-85
pubmed: 10543978
Nat Struct Biol. 1996 Jul;3(7):586-9
pubmed: 8673601
Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E468-E477
pubmed: 29282323
Cell. 1994 May 6;77(3):461-72
pubmed: 8181064
Biochemistry. 2018 Sep 4;57(35):5257-5269
pubmed: 30091902
J Biol Chem. 1998 Jan 9;273(2):729-35
pubmed: 9422724
Mol Cell. 2006 Jun 23;22(6):851-68
pubmed: 16793553
Biochemistry. 1998 Jun 23;37(25):9083-90
pubmed: 9636054
Biochemistry. 1992 Jun 16;31(23):5253-63
pubmed: 1606149
Sci Adv. 2020 Jan 31;6(5):eaay4458
pubmed: 32064351
Structure. 1994 May 15;2(5):423-38
pubmed: 7521735
J Mol Biol. 2000 Jun 2;299(2):521-35
pubmed: 10860756
Nature. 2003 Dec 11;426(6967):676-80
pubmed: 14668868
Biochemistry. 1998 May 19;37(20):7119-26
pubmed: 9585523
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3199-203
pubmed: 7536927
Mol Cell Biol. 1993 Dec;13(12):7278-87
pubmed: 7504171
J Mol Biol. 2002 Sep 20;322(3):605-20
pubmed: 12225753
J Biol Chem. 1994 May 6;269(18):13614-22
pubmed: 7513703
Cell. 1993 Mar 12;72(5):779-90
pubmed: 7680960
J Mol Biol. 2002 Feb 15;316(2):291-304
pubmed: 11851339
Biochemistry. 1995 Jan 24;34(3):1040-9
pubmed: 7530043
Cell. 1998 Feb 20;92(4):441-50
pubmed: 9491886
Biochemistry. 1997 Aug 19;36(33):10006-14
pubmed: 9254595
Sci Signal. 2010 May 04;3(120):ra34
pubmed: 20442417
Sci Signal. 2011 Dec 06;4(202):ra83
pubmed: 22155787
Science. 2002 Jan 25;295(5555):683-6
pubmed: 11743164
Biochemistry. 2005 Jan 18;44(2):694-703
pubmed: 15641795
Nature. 1998 Oct 1;395(6701):462-9
pubmed: 9774102
Nat Struct Biol. 1998 Feb;5(2):156-63
pubmed: 9461082
J Biol Chem. 2001 Sep 28;276(39):36809-16
pubmed: 11477068
Biochemistry. 1998 Nov 3;37(44):15400-7
pubmed: 9799501
Eur Biophys J. 1996;24(6):371-80
pubmed: 8765711
J Biol Chem. 2005 Sep 2;280(35):30984-93
pubmed: 15987685
Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14024-9
pubmed: 22886086
Cell. 1993 Mar 12;72(5):767-78
pubmed: 7680959
Biochemistry. 1999 Apr 20;38(16):5147-54
pubmed: 10213620
Biochemistry. 1993 Sep 21;32(37):9832-44
pubmed: 8373781
Structure. 2012 Dec 5;20(12):2062-75
pubmed: 23063561
Nature. 1992 Aug 20;358(6388):646-53
pubmed: 1379696
EMBO J. 2012 Mar 7;31(5):1308-19
pubmed: 22252131