A fast and simple SPE-LC-MS/MS procedure for extraction and quantitative analysis of 1,2,4-triazole, N,N-dimethylsulfamide, and other small polar organic compounds in groundwater.

ENVI-Carb Hypercarb LC-MS/MS PMOCs SPE Solid phase extraction

Journal

Analytical and bioanalytical chemistry

ISSN: 1618-2650

Titre abrégé: Anal Bioanal Chem

Pays: Germany

ID NLM: 101134327

Informations de publication

Date de publication:
Sep 2020

Historique:

received: 07 05 2020

accepted: 22 06 2020

revised: 12 06 2020

pubmed: 11 7 2020

medline: 11 7 2020

entrez: 11 7 2020

Statut: ppublish

Résumé

Small polar organic pollutants have been discovered to be great threats to the groundwater' as they often are highly mobile and persistent in the environment. 1,2,4-Triazole and N,N-dimethylsulfamide, two well-known examples of small polar compounds, are frequent pollutants of upper groundwater. Both are degradation products of several fungicides commonly or previously used in agriculture' but also in wood-preserving paints. A common trait in the analysis of these small polar compounds is the lack of sufficient pre-concentration methods to lower the limit of detection and enable quantitative analysis at nano-scale concentrations. To date, they are analyzed only by direct injection in HPLC-MS/MS, with detection limits just below the European threshold value for pesticides in groundwater of 0.1 μg/L. Based on a comprehensive method development, a solid phase extraction method was developed. As known LC methods for analysis of 1,2,4-triazole are based on Thermo Fisher's Hypercarb column, emphasis was placed on testing various carbon-based materials. The final, thoroughly validated extraction protocol is based on Supelco's ENVI-Carb Plus cartridges. With extraction recoveries close to 100% for 1,2,4-triazole and N,N-dimethylsulfamide and quantification limits of around 0.003 μg/L, the method enables extraction and quantification of polar pollutants at nano-scale concentration from groundwater samples. In addition, the method is very promising to be used for other small polar pollutants. Graphical abstract.

Identifiants

DOI: 10.1007/s00216-020-02788-1 PMID: 32648104

pubmed: 32648104

doi: 10.1007/s00216-020-02788-1

pii: 10.1007/s00216-020-02788-1

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

5683-5693

Subventions

Organisme : Miljøstyrelsen

ID : TriaFung (project no. MST-667-00200)

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