Oxyresveratrol extracted from Artocarpus heterophyllus Lam. inhibits tyrosinase and age pigments in vitro and in vivo.
Agaricales
/ enzymology
Animals
Apoptosis
/ drug effects
Artocarpus
/ chemistry
Caenorhabditis elegans
Melanins
/ biosynthesis
Melanoma
/ metabolism
Melanoma, Experimental
Mice
Monophenol Monooxygenase
/ antagonists & inhibitors
Oxidative Stress
/ drug effects
Plant Extracts
/ isolation & purification
Protein Conformation
/ drug effects
Skin Pigmentation
/ drug effects
Stilbenes
/ isolation & purification
Time Factors
Journal
Food & function
ISSN: 2042-650X
Titre abrégé: Food Funct
Pays: England
ID NLM: 101549033
Informations de publication
Date de publication:
01 Jul 2020
01 Jul 2020
Historique:
pubmed:
11
7
2020
medline:
4
6
2021
entrez:
11
7
2020
Statut:
ppublish
Résumé
We extracted and purified oxyresveratrol (OXY) from Artocarpus heterophyllus Lam. and identified its structure. The kinetics and mechanisms of OXY-induced mushroom tyrosinase inhibition were studied using fluorescence spectroscopy, copper ion chelation, and circular dichroism (CD). We found that OXY significantly inhibited tyrosinase with a half maximal inhibitory concentration (IC
Substances chimiques
Melanins
0
Plant Extracts
0
Stilbenes
0
puag-haad
4721-07-7
Monophenol Monooxygenase
EC 1.14.18.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM