Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma.
Adenocarcinoma of Lung
/ drug therapy
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ metabolism
Carcinogenesis
/ genetics
DNA Copy Number Variations
/ genetics
DNA Methylation
/ genetics
Female
Humans
Lung Neoplasms
/ drug therapy
Male
Middle Aged
Mutation
/ genetics
Oncogene Proteins, Fusion
Phenotype
Phosphoproteins
/ metabolism
Proteogenomics
Proteome
/ metabolism
CPTAC
acetylation
adenocarcinoma
genomics
lung cancer
mass spectrometry
phosphorylation
protein
proteogenomics
proteomics
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
09 07 2020
09 07 2020
Historique:
received:
05
11
2019
revised:
06
03
2020
accepted:
03
06
2020
entrez:
11
7
2020
pubmed:
11
7
2020
medline:
22
1
2021
Statut:
ppublish
Résumé
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and acetylproteomics. Multi-omics clustering revealed four subgroups defined by key driver mutations, country, and gender. Proteomic and phosphoproteomic data illuminated biology downstream of copy number aberrations, somatic mutations, and fusions and identified therapeutic vulnerabilities associated with driver events involving KRAS, EGFR, and ALK. Immune subtyping revealed a complex landscape, reinforced the association of STK11 with immune-cold behavior, and underscored a potential immunosuppressive role of neutrophil degranulation. Smoking-associated LUADs showed correlation with other environmental exposure signatures and a field effect in NATs. Matched NATs allowed identification of differentially expressed proteins with potential diagnostic and therapeutic utility. This proteogenomics dataset represents a unique public resource for researchers and clinicians seeking to better understand and treat lung adenocarcinomas.
Identifiants
pubmed: 32649874
pii: S0092-8674(20)30744-3
doi: 10.1016/j.cell.2020.06.013
pmc: PMC7373300
mid: NIHMS1603117
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Oncogene Proteins, Fusion
0
Phosphoproteins
0
Proteome
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
200-225.e35Subventions
Organisme : NCI NIH HHS
ID : U24 CA210985
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA210986
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES017885
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA210993
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA210979
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA214125
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA210955
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM130423
Pays : United States
Investigateurs
Alex Webster
(A)
Alicia Francis
(A)
Alyssa Charamut
(A)
Amanda G Paulovich
(AG)
Amy M Perou
(AM)
Andrew K Godwin
(AK)
Andrii Karnuta
(A)
Annette Marrero-Oliveras
(A)
Barbara Hindenach
(B)
Barbara Pruetz
(B)
Bartosz Kubisa
(B)
Brian J Druker
(BJ)
Chet Birger
(C)
Corbin D Jones
(CD)
Dana R Valley
(DR)
Daniel C Rohrer
(DC)
Daniel Cui Zhou
(DC)
Daniel W Chan
(DW)
David Chesla
(D)
David J Clark
(DJ)
Dmitry Rykunov
(D)
Donghui Tan
(D)
Elena V Ponomareva
(EV)
Elizabeth Duffy
(E)
Eric J Burks
(EJ)
Eric E Schadt
(EE)
Erik J Bergstrom
(EJ)
Eugene S Fedorov
(ES)
Ewa Malc
(E)
George D Wilson
(GD)
Hai-Quan Chen
(HQ)
Halina M Krzystek
(HM)
Hongwei Liu
(H)
Houston Culpepper
(H)
Hua Sun
(H)
Hui Zhang
(H)
Jacob Day
(J)
James Suh
(J)
Jeffrey R Whiteaker
(JR)
Jennifer Eschbacher
(J)
John McGee
(J)
Karen A Ketchum
(KA)
Karin D Rodland
(KD)
Karna Robinson
(K)
Katherine A Hoadley
(KA)
Kei Suzuki
(K)
Ki Sung Um
(KS)
Kim Elburn
(K)
Liang-Bo Wang
(LB)
Lijun Chen
(L)
Linda Hannick
(L)
Liqun Qi
(L)
Lori J Sokoll
(LJ)
Małgorzata Wojtyś
(M)
Marcin J Domagalski
(MJ)
Marina A Gritsenko
(MA)
Mary B Beasley
(MB)
Matthew E Monroe
(ME)
Matthew J Ellis
(MJ)
Maureen Dyer
(M)
Meghan C Burke
(MC)
Melissa Borucki
(M)
Meng-Hong Sun
(MH)
Michael H Roehrl
(MH)
Michael J Birrer
(MJ)
Michael Noble
(M)
Michael Schnaubelt
(M)
Michael Vernon
(M)
Michelle Chaikin
(M)
Mikhail Krotevich
(M)
Munziba Khan
(M)
Myvizhi Esai Selvan
(ME)
Nancy Roche
(N)
Nathan J Edwards
(NJ)
Negin Vatanian
(N)
Olga Potapova
(O)
Pamela Grady
(P)
Peter B McGarvey
(PB)
Piotr Mieczkowski
(P)
Pushpa Hariharan
(P)
Rashna Madan
(R)
Ratna R Thangudu
(RR)
Richard D Smith
(RD)
Robert J Welsh
(RJ)
Robert Zelt
(R)
Rohit Mehra
(R)
Ronald Matteotti
(R)
Sailaja Mareedu
(S)
Samuel H Payne
(SH)
Sandra Cottingham
(S)
Sanford P Markey
(SP)
Seema Chugh
(S)
Shaleigh Smith
(S)
Shirley Tsang
(S)
Shuang Cai
(S)
Simina M Boca
(SM)
Sonya Carter
(S)
Stacey Gabriel
(S)
Stephanie De Young
(S)
Stephen E Stein
(SE)
Sunita Shankar
(S)
Tanya Krubit
(T)
Tao Liu
(T)
Tara Skelly
(T)
Thomas Bauer
(T)
Uma Velvulou
(U)
Umut Ozbek
(U)
Vladislav A Petyuk
(VA)
Volodymyr Sovenko
(V)
William E Bocik
(WE)
William W Maggio
(WW)
Xi Chen
(X)
Yan Shi
(Y)
Yige Wu
(Y)
Yingwei Hu
(Y)
Yuxing Liao
(Y)
Zhen Zhang
(Z)
Zhiao Shi
(Z)
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests B.Z. has received research funding from Bristol-Myers Squibb. All other authors have no conflict of interests to declare.
Références
Oncogenesis. 2019 Feb 26;8(3):18
pubmed: 30808864
Mol Cell Proteomics. 2019 Aug 9;18(8 suppl 1):S169-S182
pubmed: 31213479
Biochimie. 2015 Apr;111:10-8
pubmed: 25645980
Immunotherapy. 2016 Feb;8(2):145-63
pubmed: 26808918
Cell Rep. 2018 Apr 3;23(1):227-238.e3
pubmed: 29617662
Lung Cancer. 2000 Jan;27(1):19-26
pubmed: 10672780
Curr Biol. 2012 Nov 6;22(21):2063-8
pubmed: 23063435
Cancer Med. 2016 Dec;5(12):3489-3499
pubmed: 27774777
J Proteome Res. 2019 Jan 4;18(1):542-547
pubmed: 30351145
Oncotarget. 2017 Mar 28;8(13):21461-21471
pubmed: 28423523
Clin Chem Lab Med. 2018 Apr 25;56(5):702-717
pubmed: 29305565
Exp Cell Res. 2013 Sep 10;319(15):2337-42
pubmed: 23830877
Nat Med. 2012 Feb 12;18(3):378-81
pubmed: 22327623
Transl Oncol. 2019 Mar;12(3):485-492
pubmed: 30594037
Nucleic Acids Res. 2019 Jan 8;47(D1):D941-D947
pubmed: 30371878
J Clin Invest. 2018 Mar 1;128(3):970-984
pubmed: 29400695
Mol Cell Proteomics. 2019 Mar;18(3):576-593
pubmed: 30563849
Blood. 2011 May 12;117(19):5112-22
pubmed: 21403126
Nature. 2012 Mar 28;483(7391):603-7
pubmed: 22460905
Bioinformatics. 2018 Jul 1;34(13):i528-i536
pubmed: 29949994
J Immunol. 2000 Jun 15;164(12):6503-8
pubmed: 10843708
J Proteome Res. 2016 Mar 4;15(3):743-54
pubmed: 26733076
Cancer Res. 2017 Jun 15;77(12):3306-3316
pubmed: 28428278
Nucleic Acids Res. 2014 Jan;42(Database issue):D472-7
pubmed: 24243840
Biostatistics. 2007 Jan;8(1):118-27
pubmed: 16632515
Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4164-9
pubmed: 15016911
Sci Rep. 2017 Aug 24;7(1):9389
pubmed: 28839225
Genome Biol. 2011;12(4):R41
pubmed: 21527027
Cell. 2018 Apr 5;173(2):371-385.e18
pubmed: 29625053
J Clin Oncol. 2017 May 1;35(13):1403-1410
pubmed: 28447912
Nat Commun. 2020 Jan 17;11(1):359
pubmed: 31953384
J Biol Chem. 2005 Feb 18;280(7):5350-60
pubmed: 15574420
N Engl J Med. 2014 Nov 20;371(21):1963-71
pubmed: 25264305
Nat Rev Cancer. 2006 Apr;6(4):307-20
pubmed: 16557282
Nature. 2016 May 25;534(7605):55-62
pubmed: 27251275
Nat Rev Cancer. 2010 Dec;10(12):842-57
pubmed: 21102635
Proteomics. 2013 Nov;13(21):3131-44
pubmed: 23956138
Nat Biotechnol. 2013 Mar;31(3):213-9
pubmed: 23396013
Nat Commun. 2014 Oct 31;5:5277
pubmed: 25358478
Bioinformatics. 2019 Apr 1;35(7):1249-1251
pubmed: 30169737
Nucleic Acids Res. 2010 Jan;38(Database issue):D480-7
pubmed: 19948758
Genome Biol. 2008;9(8):R127
pubmed: 18700987
J Biol Chem. 2010 Oct 22;285(43):33540-33548
pubmed: 20724475
Nature. 2017 Jun 1;546(7656):168-172
pubmed: 28538732
PLoS One. 2013 Sep 23;8(9):e74775
pubmed: 24086370
PLoS Comput Biol. 2014 Aug 14;10(8):e1003790
pubmed: 25122495
Cell. 2019 Jul 11;178(2):316-329.e18
pubmed: 31257023
Expert Opin Ther Targets. 2008 Aug;12(8):1021-33
pubmed: 18620523
J Biol Chem. 2002 Mar 15;277(11):9498-504
pubmed: 11779868
Bioinformatics. 2010 Jun 15;26(12):1572-3
pubmed: 20427518
Oncogene. 2015 Jul 30;34(31):4019-31
pubmed: 25328138
Oncol Rep. 2019 Feb;41(2):789-800
pubmed: 30535441
Nat Commun. 2020 Apr 9;11(1):1759
pubmed: 32273506
Cell. 2018 Nov 1;175(4):984-997.e24
pubmed: 30388455
Nature. 2014 Jul 31;511(7511):543-50
pubmed: 25079552
Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9280-E9289
pubmed: 29078376
Cell Death Differ. 2014 May;21(5):685-95
pubmed: 24464223
Mol Cell Proteomics. 2005 Dec;4(12):1920-32
pubmed: 16127175
Nat Med. 2012 Mar 04;18(4):529-37
pubmed: 22388088
J Cell Mol Med. 2019 Jun;23(6):3905-3915
pubmed: 30932331
Science. 2013 Mar 29;339(6127):1546-58
pubmed: 23539594
Cell. 2006 Feb 10;124(3):631-44
pubmed: 16469707
Mol Cancer. 2011 Jul 03;10:79
pubmed: 21722395
J Clin Oncol. 2020 Feb 10;38(5):496-520
pubmed: 31381464
R J. 2016 Aug;8(1):289-317
pubmed: 27818791
J Histochem Cytochem. 1990 Sep;38(9):1313-21
pubmed: 2201737
Genes Cancer. 2010 Oct;1(10):994-1007
pubmed: 21442024
Nucleic Acids Res. 2012 Jan;40(Database issue):D261-70
pubmed: 22135298
Eur J Cancer. 2012 Dec;48(18):3405-13
pubmed: 22840368
J Clin Oncol. 2007 Feb 10;25(5):561-70
pubmed: 17290066
Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3452-3457
pubmed: 29540569
Oncotarget. 2015 Mar 20;6(8):6191-202
pubmed: 25730908
Cancer Res. 2012 Dec 15;72(24):6351-61
pubmed: 23135912
Nucleic Acids Res. 2018 Jan 4;46(D1):D1068-D1073
pubmed: 29156001
Nucleic Acids Res. 2017 Jul 3;45(W1):W130-W137
pubmed: 28472511
Contemp Oncol (Pozn). 2018 Mar;22(1A):23-32
pubmed: 29628790
Clin Proteomics. 2016 Oct 27;13:31
pubmed: 27799870
Dis Markers. 2006;22(5-6):277-91
pubmed: 17264398
Cell Rep. 2013 Sep 26;4(6):1116-30
pubmed: 24055055
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
BMC Genomics. 2005 Oct 20;6:145
pubmed: 16242023
Genes Cancer. 2011 Mar;2(3):298-305
pubmed: 21779500
J Hematol Oncol. 2018 Aug 2;11(1):100
pubmed: 30068361
Cell Growth Differ. 1996 Dec;7(12):1589-97
pubmed: 8959326
Oncotarget. 2017 Sep 27;8(55):93672-93687
pubmed: 29212181
Nat Genet. 2016 Jun;48(6):607-16
pubmed: 27158780
J Thorac Oncol. 2010 May;5(5):585-90
pubmed: 20234320
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Hum Pathol. 2015 Feb;46(2):217-24
pubmed: 25466965
BMC Bioinformatics. 2010 Jul 02;11:367
pubmed: 20598126
Cell. 2017 Nov 30;171(6):1437-1452.e17
pubmed: 29195078
Nature. 2016 Jul 7;535(7610):148-52
pubmed: 27362227
Nature. 2008 Oct 23;455(7216):1069-75
pubmed: 18948947
Cell. 2016 Jul 28;166(3):755-765
pubmed: 27372738
Nature. 2018 Jan 24;553(7689):446-454
pubmed: 29364287
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560
pubmed: 30683722
Bioinformatics. 2007 Jun 15;23(12):1495-502
pubmed: 17483501
Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7335-9
pubmed: 8041791
Science. 2008 Oct 10;322(5899):271-5
pubmed: 18845758
Cell Res. 2009 Feb;19(2):156-72
pubmed: 19153598
Clin Cancer Res. 2002 Jul;8(7):2298-305
pubmed: 12114434
Sci Rep. 2016 Dec 20;6:39044
pubmed: 27996048
Cancer Res. 2010 Sep 1;70(17):6746-56
pubmed: 20713529
Lung Cancer. 2016 Dec;102:122-134
pubmed: 27987580
Genome Res. 2019 Mar;29(3):485-493
pubmed: 30610011
Oncoimmunology. 2016 Oct 18;5(12):e1240857
pubmed: 28123876
Nature. 2019 Mar;567(7746):49-55
pubmed: 30814735
Cell. 2019 Jul 11;178(2):330-345.e22
pubmed: 31257027
Oncol Lett. 2018 Nov;16(5):5753-5760
pubmed: 30344729
Nat Commun. 2020 Jan 27;11(1):532
pubmed: 31988290
BMC Bioinformatics. 2017 Mar 2;18(1):142
pubmed: 28249561
Pharmacol Res. 2019 Jan;139:503-511
pubmed: 30366101
Cell. 2018 Jun 28;174(1):231-244.e12
pubmed: 29804834
Onco Targets Ther. 2018 Jan 26;11:571-585
pubmed: 29416358
Am J Hum Genet. 2009 Jan;84(1):52-9
pubmed: 19100526
Sci Data. 2017 Mar 28;4:170030
pubmed: 28350385
Cancer Res. 2014 Oct 15;74(20):5891-902
pubmed: 25164010
Cell. 2020 Feb 20;180(4):729-748.e26
pubmed: 32059776
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Nat Genet. 2016 Jun;48(6):600-606
pubmed: 27111033
Eur J Cancer. 2018 Sep;101:20-29
pubmed: 30014971
Oncol Lett. 2017 Apr;13(4):2021-2026
pubmed: 28454357
Cancer Lett. 2000 Mar 31;150(2):155-64
pubmed: 10704737
Lung Cancer. 2019 Feb;128:26-32
pubmed: 30642449
Mol Cell Proteomics. 2016 Mar;15(3):1060-71
pubmed: 26631509
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nature. 2009 Nov 5;462(7269):108-12
pubmed: 19847166
Nat Immunol. 2015 Jan;16(1):27-35
pubmed: 25521682
Cancer. 2008 Jun 15;112(12):2676-82
pubmed: 18412154
Oncotarget. 2015 Jun 20;6(17):15425-35
pubmed: 26029996
IEEE Trans Pattern Anal Mach Intell. 2013 Jul;35(7):1592-605
pubmed: 23681989
Oncogene. 2004 Apr 22;23(19):3376-84
pubmed: 14990988
Science. 2004 Jun 4;304(5676):1497-500
pubmed: 15118125
Free Radic Biol Med. 2015 Nov;88(Pt B):101-107
pubmed: 26057936
Onco Targets Ther. 2016 Mar 01;9:1047-55
pubmed: 27042097
Bioinformatics. 2013 Dec 15;29(24):3235-7
pubmed: 24058055
J Clin Invest. 2017 Aug 1;127(8):3090-3102
pubmed: 28714863
Int J Mol Sci. 2018 May 25;19(6):
pubmed: 29799467
Cancers (Basel). 2019 Jul 30;11(8):
pubmed: 31366041
Cell. 2019 May 2;177(4):821-836.e16
pubmed: 30982602
J Thromb Haemost. 2008 Apr;6(4):601-8
pubmed: 18208538
PLoS One. 2012;7(5):e36530
pubmed: 22590557
Prog Clin Biol Res. 1987;248:263-81
pubmed: 2823286
Nucleic Acids Res. 2016 Jan 8;44(1):e3
pubmed: 26271990
J Clin Pathol. 1993 Jan;46(1):18-22
pubmed: 8432883
Cancer Res. 1994 Dec 1;54(23):6133-6
pubmed: 7954459
Stem Cell Reports. 2016 Jul 12;7(1):110-25
pubmed: 27293150
Nucleic Acids Res. 2014 Jan;42(Database issue):D478-84
pubmed: 24203708
Nucleic Acids Res. 2009 Jan;37(Database issue):D816-9
pubmed: 18838390
J Exp Med. 1998 Jun 1;187(11):1863-70
pubmed: 9607926
J BUON. 2013 Apr-Jun;18(2):352-8
pubmed: 23818345
Front Immunol. 2012 Jun 07;3:131
pubmed: 22701116
Med Oncol. 2019 Jul 24;36(9):76
pubmed: 31342270
Nucleic Acids Res. 2016 May 5;44(8):e71
pubmed: 26704973
J Immunol. 2004 Mar 1;172(5):3319-27
pubmed: 14978140
J Immunol. 2017 Nov 1;199(9):3360-3368
pubmed: 28978689
Pathol Int. 2018 Nov;68(11):596-604
pubmed: 30320419
Carcinogenesis. 2008 Oct;29(10):1938-43
pubmed: 18676680
BMC Bioinformatics. 2013 Jan 16;14:7
pubmed: 23323831
Hepatoma Res. 2018;4:
pubmed: 32258418
Bioinformatics. 2009 Nov 1;25(21):2865-71
pubmed: 19561018
Pac Symp Biocomput. 2016;21:405-16
pubmed: 26776204
Cancer Biomark. 2019;24(3):371-382
pubmed: 30883337
Respir Res. 2018 May 9;19(1):88
pubmed: 29743116
Clin Genet. 2005 Aug;68(2):128-36
pubmed: 15996209
Neonatology. 2014;105(4):337-43
pubmed: 24931326
Nat Methods. 2018 Aug;15(8):591-594
pubmed: 30013048
Mol Cell Biol. 2014 Mar;34(5):832-46
pubmed: 24366543
Nat Protoc. 2018 Jul;13(7):1632-1661
pubmed: 29988108
Amino Acids. 2015 Jun;47(6):1239-46
pubmed: 25743165
Genome Biol. 2011;12(1):R1
pubmed: 21205303
F1000Res. 2016 Jun 08;5:1281
pubmed: 27347385
Anticancer Res. 2016 Dec;36(12):6207-6224
pubmed: 27919939
Genome Biol. 2014 Dec 03;15(12):503
pubmed: 25599564
Cell Rep. 2015 Sep 29;12(12):1978-85
pubmed: 26365186
Sci Transl Med. 2013 Oct 30;5(209):209ra153
pubmed: 24174329
Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16570-5
pubmed: 23012423
Cell. 2012 Sep 14;150(6):1107-20
pubmed: 22980975
Nature. 2007 Dec 6;450(7171):893-8
pubmed: 17982442
Nat Commun. 2015 Dec 07;6:8866
pubmed: 26638776
Int J Cancer. 2003 Jun 20;105(3):371-6
pubmed: 12704671
Onco Targets Ther. 2018 Jun 19;11:3541-3549
pubmed: 29950859
Nucleic Acids Res. 2018 Jan 4;46(D1):D649-D655
pubmed: 29145629
PLoS One. 2017 Aug 21;12(8):e0182468
pubmed: 28827793
Cancer Res. 2007 May 15;67(10):4620-9
pubmed: 17510387
Proc Am Thorac Soc. 2008 Dec 1;5(8):811-5
pubmed: 19017734
Cell. 2017 Jul 27;170(3):564-576.e16
pubmed: 28753430
Tumour Biol. 2013 Oct;34(5):2599-603
pubmed: 23609034
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
N Engl J Med. 2004 May 20;350(21):2129-39
pubmed: 15118073
Genome Res. 2012 Mar;22(3):568-76
pubmed: 22300766
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13754-8
pubmed: 19666584
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Nat Med. 2012 Feb 12;18(3):375-7
pubmed: 22327624
Mol Cell Proteomics. 2019 Aug 9;18(8 suppl 1):S52-S65
pubmed: 31227599
Cancer Res. 2009 Sep 15;69(18):7252-61
pubmed: 19706765
Cancer Cell. 2017 Jun 12;31(6):848-848.e1
pubmed: 28609660
Nat Commun. 2013;4:2612
pubmed: 24113773
Nature. 2014 Jan 16;505(7483):412-6
pubmed: 24317696
Mol Cell Biochem. 2015 Apr;402(1-2):75-82
pubmed: 25567207
Bioinformatics. 2012 Jul 15;28(14):1811-7
pubmed: 22581179
J Proteome Res. 2021 Jul 2;20(7):3767-3773
pubmed: 34165986
Cell. 2008 Jun 27;133(7):1292-1292.e1
pubmed: 18585361
Cell Death Dis. 2019 Jan 18;10(2):52
pubmed: 30718464
Mol Cell. 2001 Oct;8(4):759-69
pubmed: 11684012
Cell. 2018 Apr 5;173(2):321-337.e10
pubmed: 29625050
J Proteome Res. 2012 Feb 3;11(2):1009-17
pubmed: 22103967
PLoS One. 2012;7(8):e42264
pubmed: 22870311
Nat Struct Mol Biol. 2004 Apr;11(4):308-15
pubmed: 15004546
Genome Biol. 2017 Nov 15;18(1):220
pubmed: 29141660
Nucleic Acids Res. 2016 Jun 20;44(11):e108
pubmed: 27060149
J Cell Physiol. 2019 Sep;234(9):16592-16600
pubmed: 30805927
Nucleic Acids Res. 2018 Jan 4;46(D1):D956-D963
pubmed: 29136207
N Engl J Med. 2010 Oct 28;363(18):1693-703
pubmed: 20979469
Nat Immunol. 2013 Dec;14(12):1212-8
pubmed: 24240160
Cell. 2018 Apr 5;173(2):338-354.e15
pubmed: 29625051
Mol Cell Proteomics. 2015 Sep;14(9):2429-40
pubmed: 25953088
Int J Cancer. 2012 Apr 15;130(8):1733-44
pubmed: 21544811
Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):212-220
pubmed: 28400131
Cancer Res. 2002 Feb 15;62(4):982-5
pubmed: 11861368
Cancer Med. 2018 Jan;7(1):157-166
pubmed: 29168346
Drug Resist Updat. 2017 Nov;33-35:36-42
pubmed: 29145973
J Biol Chem. 2007 Apr 13;282(15):11221-9
pubmed: 17287208
Cell. 1994 Sep 23;78(6):949-61
pubmed: 7923364
Nat Rev Cancer. 2007 Oct;7(10):778-90
pubmed: 17882278
Science. 2006 Sep 29;313(5795):1929-35
pubmed: 17008526
Bioinformatics. 2014 Dec 1;30(23):3310-6
pubmed: 25143287
Front Oncol. 2017 May 04;7:85
pubmed: 28523248