High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification.
Journal
Biochimie
ISSN: 1638-6183
Titre abrégé: Biochimie
Pays: France
ID NLM: 1264604
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
25
05
2020
revised:
02
07
2020
accepted:
02
07
2020
pubmed:
11
7
2020
medline:
15
12
2020
entrez:
11
7
2020
Statut:
ppublish
Résumé
It is becoming obvious that in addition to aging and various hearth pathologies, excess of body weight, especially obesity is a major risk factor for severity of COVID-19 infection. Intriguingly the receptor for SARS-CoV-2 is ACE2, a member of the angiotensin receptor family that has a relatively large tissue distribution. This observation likely explains the multitude of symptoms that have been described from human patients. The adipose tissue also expresses ACE2, suggesting that adipocytes are potentially infected by SARS-CoV-2. Here we discuss some of the potential contribution of the adipose tissue to the severity of the infection and propose some aspects of obese patients metabolic phenotyping to help stratification of individuals with high risk of severe disease.
Identifiants
pubmed: 32649962
pii: S0300-9084(20)30155-3
doi: 10.1016/j.biochi.2020.07.001
pmc: PMC7340594
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
257-265Informations de copyright
Copyright © 2020 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None.
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