Biotransformation of contraceptive drug desogestrel with Cunninghamella elegans, and anti-inflammatory activity of its metabolites.
Anti-inflammatory
Biotransformation
Cunninghamella elegans
Desogestrel
T-cells proliferation
TNF-α inhibition
Journal
Steroids
ISSN: 1878-5867
Titre abrégé: Steroids
Pays: United States
ID NLM: 0404536
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
12
02
2020
revised:
25
06
2020
accepted:
30
06
2020
pubmed:
11
7
2020
medline:
16
6
2021
entrez:
11
7
2020
Statut:
ppublish
Résumé
Biotransformation of an orally active contraceptive drug, desogestrel (1), with Cunninghamella elegans yielded a new metabolite, 13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17β-ol-3,6-dione (2), along with five known metabolites, i.e., 13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-3β,6β,17β-triol (3), 13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-6β,17β-diol-3-one (4), 13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17β-ol-3-one (5), 13β-ethyl-11-epoxy-18,19-dinor-17α-pregn-4-en-20-yn-17β-ol-3-one (6), and 13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-10β,17β-diol-3-one (7). The structure of new metabolite 2 was elucidated by using
Identifiants
pubmed: 32650000
pii: S0039-128X(20)30120-3
doi: 10.1016/j.steroids.2020.108694
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Contraceptive Agents
0
Desogestrel
81K9V7M3A3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108694Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.