Familial clustering of neuromyelitis optica and multiple sclerosis: clues pointing towards shared risks?
Epidemiology
Family
Multiple sclerosis
Neuromyelitis optica
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
11
05
2020
revised:
08
06
2020
accepted:
04
07
2020
pubmed:
11
7
2020
medline:
15
5
2021
entrez:
11
7
2020
Statut:
ppublish
Résumé
We examine the prevalence of the familial association of concordant NMOSD/NMOSD and discordant NMOSD/MS cases among a large NMOSD cohort. Familial association was examined in a monocenter cohort of 119 NMOSD patients and 45 patients at high risk of NMOSD from French West Indies. Data mining gathered 31 multiplex families. Twin monozygotic sisters concordant for NMOSD/NMOSD, and four discordant NMOSD/MS families, accounted respectively for 0.8% and 3.4% of the NMOSD cohort. Familial clustering was more frequent than random association. In discordant NMOSD/MS families, the NMOSD patient was always from the parental generation. The non-random successive familial cases of NMOSD and MS suggest a change of risk factor over generations.
Identifiants
pubmed: 32650123
pii: S2211-0348(20)30446-6
doi: 10.1016/j.msard.2020.102371
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102371Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.