The Association of rs1898830 in
association analysis
cardiovascular diseases
hypertension
lipids
rs1898830
single nucleotide polymorphisms
toll-like receptor 2
Journal
Journal of cardiovascular development and disease
ISSN: 2308-3425
Titre abrégé: J Cardiovasc Dev Dis
Pays: Switzerland
ID NLM: 101651414
Informations de publication
Date de publication:
08 Jul 2020
08 Jul 2020
Historique:
received:
08
06
2020
revised:
29
06
2020
accepted:
06
07
2020
entrez:
12
7
2020
pubmed:
12
7
2020
medline:
12
7
2020
Statut:
epublish
Résumé
Toll-like receptors (TLRs) are important components of the innate immune system, involved in establishing immunity to infections. Apart from being implicated in immunity, numerous studies have reported that many TLRs, including TLR2, are involved in the pathogenesis of cardiovascular diseases and their risk factors. Since rs1898830 is associated with TLR2-mediated cellular activation, we aimed to study its association with CVD risk factors, such as lipid levels and hypertension. A cross-sectional study was conducted on 460 individuals free from chronic diseases. Clinical and biological data were collected and DNA was extracted and genotyped using Kompetitive allele specific PCR (KASP™). Multiple logistic regression models, adjusted for six covariates, were used. A power calculation analysis was also performed. We found that rs1898830 in The present results provide additional evidence supporting the implication of TLR2 in CVD risk factors.
Sections du résumé
BACKGROUND AND OBJECTIVE
OBJECTIVE
Toll-like receptors (TLRs) are important components of the innate immune system, involved in establishing immunity to infections. Apart from being implicated in immunity, numerous studies have reported that many TLRs, including TLR2, are involved in the pathogenesis of cardiovascular diseases and their risk factors. Since rs1898830 is associated with TLR2-mediated cellular activation, we aimed to study its association with CVD risk factors, such as lipid levels and hypertension.
METHODS
METHODS
A cross-sectional study was conducted on 460 individuals free from chronic diseases. Clinical and biological data were collected and DNA was extracted and genotyped using Kompetitive allele specific PCR (KASP™). Multiple logistic regression models, adjusted for six covariates, were used. A power calculation analysis was also performed.
RESULTS
RESULTS
We found that rs1898830 in
CONCLUSION
CONCLUSIONS
The present results provide additional evidence supporting the implication of TLR2 in CVD risk factors.
Identifiants
pubmed: 32650372
pii: jcdd7030024
doi: 10.3390/jcdd7030024
pmc: PMC7569770
pii:
doi:
Types de publication
Journal Article
Langues
eng
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