HLA Evolutionary Divergence as a Prognostic Marker for AML Patients Undergoing Allogeneic Stem Cell Transplantation.
AML
HLA evolutionary divergence
acute myeloid leukemia
allogeneic stem cell transplantation
graft-versus-leukemia effect
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
08 Jul 2020
08 Jul 2020
Historique:
received:
15
06
2020
revised:
03
07
2020
accepted:
06
07
2020
entrez:
12
7
2020
pubmed:
12
7
2020
medline:
12
7
2020
Statut:
epublish
Résumé
The diversity of human leukocyte antigens (HLAs) enables the presentation of immense repertoires of peptides, including tumor-associated antigens (TAAs). As a surrogate for immunopeptidome diversity, the HLA evolutionary divergence (HED) between individual HLA alleles might directly define the ability to present TAAs, a prerequisite for graft-versus-leukemia effects. We therefore analyzed the impact of HED on survival within a cohort of 171 acute myeloid leukemia (AML) patients after matched donor allogeneic hematopoietic stem cell transplantation (HSCT). Low HED (<25th percentile) of HLA class I (HED
Identifiants
pubmed: 32650450
pii: cancers12071835
doi: 10.3390/cancers12071835
pmc: PMC7408841
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : WA 4608/1-2
Organisme : Deutsche Forschungsgemeinschaft
ID : EXC2180-390900677
Organisme : Wilhelm Sander-Stiftung
ID : 2016.177.2
Organisme : José Carreras Leukämie-Stiftung
ID : DJCLS 05 R/2017
Organisme : Fortüne program, University of Tübingen
ID : 2581-0-0
Organisme : Fortüne program, University of Tübingen
ID : 2451-0-0
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