Enteroviruses and T1D: Is It the Virus, the Genes or Both which Cause T1D.
HLA
Hippo
IF1H1
IFIH1
TLR3
YAP
beta-cell
coxsackievirus
enterovirus
type 1 diabetes
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
08 Jul 2020
08 Jul 2020
Historique:
received:
15
06
2020
revised:
04
07
2020
accepted:
06
07
2020
entrez:
12
7
2020
pubmed:
12
7
2020
medline:
12
7
2020
Statut:
epublish
Résumé
Type 1 diabetes (T1D) is a chronic autoimmune disorder that results from the selective destruction of insulin-producing β-cells in the pancreas. Up to now, the mechanisms triggering the initiation and progression of the disease are, in their complexity, not fully understood and imply the disruption of several tolerance networks. Viral infection is one of the environmental factors triggering diabetes, which is initially based on the observation that the disease's incidence follows a periodic pattern within the population. Moreover, the strong correlation of genetic susceptibility is a prerequisite for enteroviral infection associated islet autoimmunity. Epidemiological data and clinical findings indicate enteroviral infections, mainly of the coxsackie B virus family, as potential pathogenic mechanisms to trigger the autoimmune reaction towards β-cells, resulting in the boost of inflammation following β-cell destruction and the onset of T1D. This review discusses previously identified virus-associated genetics and pathways of β-cell destruction. Is it the virus itself which leads to β-cell destruction and T1D progression? Or is it genetic, so that the virus may activate auto-immunity and β-cell destruction only in genetically predisposed individuals?
Identifiants
pubmed: 32650582
pii: microorganisms8071017
doi: 10.3390/microorganisms8071017
pmc: PMC7409303
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : KM
Organisme : Juvenile Diabetes Research Foundation United States of America
ID : KM
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