The Role of Matrix Metalloproteinases in Periodontal Disease.
MMP
collagenases
matrix metalloproteinases
periodontal disease
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
08 07 2020
08 07 2020
Historique:
received:
26
04
2020
revised:
03
07
2020
accepted:
06
07
2020
entrez:
12
7
2020
pubmed:
12
7
2020
medline:
1
12
2020
Statut:
epublish
Résumé
This review provides a detailed description of matrix metalloproteinases (MMPs), focusing on those that are known to have critical roles in bone and periodontal disease. Periodontal disease is an inflammatory process initiated by anaerobic bacteria, which promote the host immune response in the form of a complex network of molecular pathways involving proinflammatory mediators such as cytokines, growth factors, and MMPs. MMPs are a family of 23 endopeptidases, collectively capable of degrading virtually all extracellular matrix (ECM) components. This study critically discusses the available research concerning the involvement of the MMPs in periodontal disease development and progression and presents possible therapeutic strategies. MMPs participate in morphogenesis, physiological tissue turnover, and pathological tissue destruction. Alterations in the regulation of MMP activity are implicated in the manifestation of oral diseases, and MMPs comprise the most important pathway in tissue destruction associated with periodontal disease. MMPs can be considered a risk factor for periodontal disease, and measurements of MMP levels may be useful markers for early detection of periodontitis and as a tool to assess prognostic follow-ups. Detection and inhibition of MMPs could, therefore, be useful in periodontal disease prevention or be an essential part of periodontal disease therapy, which, considering the huge incidence of the disease, may greatly improve oral health globally.
Identifiants
pubmed: 32650590
pii: ijerph17144923
doi: 10.3390/ijerph17144923
pmc: PMC7399864
pii:
doi:
Substances chimiques
Cytokines
0
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Dent Res. 2014 Mar;93(3):263-8
pubmed: 24334409
J Periodontal Res. 2006 Oct;41(5):411-7
pubmed: 16953818
Calcif Tissue Int. 1997 Jul;61(1):59-61
pubmed: 9192515
Oral Dis. 2011 Jan;17(1):115-22
pubmed: 20659259
Arch Biochem Biophys. 2013 Jul 15;535(2):111-4
pubmed: 23541862
J Oral Sci. 2008 Mar;50(1):53-6
pubmed: 18403884
J Dent Res. 2004 Mar;83(3):216-21
pubmed: 14981122
Int J Oral Maxillofac Implants. 2004 Jan-Feb;19(1):38-43
pubmed: 14982353
Bone Miner. 1994 Aug;26(2):95-107
pubmed: 7994190
Acta Odontol Scand. 2007 Feb;65(1):1-13
pubmed: 17354089
Semin Cell Dev Biol. 2009 Apr;20(2):126-37
pubmed: 19049889
J Periodontol. 2009 Mar;80(3):436-46
pubmed: 19254128
J Periodontal Res. 2012 Feb;47(1):121-8
pubmed: 21958332
J Periodontol. 2006 Apr;77(4):664-71
pubmed: 16584348
J Dent Res. 2000 Dec;79(12):1969-77
pubmed: 11201047
Annu Rev Cell Dev Biol. 2001;17:463-516
pubmed: 11687497
J Periodontol. 2006 Dec;77(12):2040-50
pubmed: 17209789
J Dent Res. 2006 Jan;85(1):59-63
pubmed: 16373682
Indian J Dent Res. 2018 Nov-Dec;29(6):799-807
pubmed: 30589011
Arch Oral Biol. 2011 Oct;56(10):1081-90
pubmed: 21481333
Clin Oral Investig. 2013 Jan;17(1):311-6
pubmed: 22382449
Microsc Res Tech. 2003 Aug 15;61(6):504-13
pubmed: 12879418
Cancer Res. 2008 Nov 15;68(22):9147-56
pubmed: 19010886
J Dent Res. 2012 Apr;91(4):420-5
pubmed: 22266526
J Periodontal Res. 2004 Feb;39(1):20-6
pubmed: 14687223
J Periodontol. 1985 Nov;56(11 Suppl):93-7
pubmed: 3001266
J Clin Periodontol. 2010 Feb;37(2):180-90
pubmed: 19995403
Int J Oral Maxillofac Implants. 2008 Jul-Aug;23(4):653-8
pubmed: 18807561
Nat Biotechnol. 1999 Aug;17(8):768-74
pubmed: 10429241
J Clin Periodontol. 2009 Dec;36(12):1011-7
pubmed: 19929954
J Rheumatol. 1998 May;25(5):975-82
pubmed: 9598901
Adv Dent Res. 1998 Nov;12(2):12-26
pubmed: 9972117
Acta Odontol Scand. 2008 Aug;66(4):219-24
pubmed: 18615324
J Clin Periodontol. 2006 Jul;33(7):462-8
pubmed: 16820033
Crit Rev Oncol Hematol. 2004 Mar;49(3):187-98
pubmed: 15036259
J Periodontal Res. 2003 Aug;38(4):436-9
pubmed: 12828663
J Dent Res. 1987 Aug;66(8):1310-4
pubmed: 3040832
Biochim Biophys Acta. 2000 Mar 7;1477(1-2):267-83
pubmed: 10708863
Periodontol 2000. 2020 Feb;82(1):186-204
pubmed: 31850625
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2824-9
pubmed: 18287018
J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 1):199-208
pubmed: 27469569
Int J Mol Sci. 2017 Feb 17;18(2):
pubmed: 28218665
Toxicology. 2004 Oct 15;203(1-3):211-20
pubmed: 15363596
J Oral Pathol Med. 2010 Sep;39(8):592-8
pubmed: 20412401
J Clin Periodontol. 2002 Jul;29(7):651-6
pubmed: 12354091
J Clin Periodontol. 2010 Jun;37(6):487-93
pubmed: 20507371
J Periodontal Res. 2005 Jun;40(3):199-207
pubmed: 15853964
Inflamm Res. 2001 Mar;50(3):175-82
pubmed: 11339506
J Periodontal Res. 2003 Aug;38(4):400-4
pubmed: 12828657
Dent Mater. 2013 Oct;29(10):999-1011
pubmed: 23953737
EMBO J. 2004 Aug 4;23(15):3020-30
pubmed: 15257288
Clin Chim Acta. 2009 Nov;409(1-2):117-22
pubmed: 19751716
J Periodontal Res. 2006 Dec;41(6):503-12
pubmed: 17076774
Biochim Biophys Acta. 2010 Jan;1803(1):20-8
pubmed: 19374923
Recent Pat Anticancer Drug Discov. 2010 Jun;5(2):109-41
pubmed: 19951249
Proc Natl Acad Sci U S A. 1990 Jul;87(14):5578-82
pubmed: 2164689
J Biol Chem. 1998 Nov 27;273(48):32347-52
pubmed: 9822715
Clin Sci (Lond). 2007 Jun;112(11):567-75
pubmed: 17241109
Circ Res. 2003 May 2;92(8):827-39
pubmed: 12730128
J Clin Periodontol. 2001 Apr;28(4):353-9
pubmed: 11314892
Br J Clin Pharmacol. 2017 Mar;83(3):444-454
pubmed: 27718252
J Surg Res. 2003 May 1;111(1):45-52
pubmed: 12842447
J Periodontal Res. 2013 Jun;48(3):357-66
pubmed: 23058002
Genome Biol. 2003;4(6):216
pubmed: 12801404
Connect Tissue Res. 1998;39(1-3):69-73; discussion 141-9
pubmed: 11062989
J Periodontol. 2006 Nov;77(11):1803-8
pubmed: 17076603
Bioorg Med Chem. 2008 Oct 1;16(19):8781-94
pubmed: 18790648
Bone. 1998 Jan;22(1):33-8
pubmed: 9437511
J Clin Periodontol. 2012 Aug;39(8):707-16
pubmed: 22671570
Invest New Drugs. 1997;15(1):61-75
pubmed: 9195290
J Bone Miner Res. 1993 Oct;8(10):1247-53
pubmed: 8256662
J Mol Biol. 2007 May 11;368(4):1101-13
pubmed: 17379243
Biopolymers. 2002;66(1):19-32
pubmed: 12228918
J Clin Periodontol. 2017 Jan;44(1):51-57
pubmed: 27801940
Ann N Y Acad Sci. 1994 Sep 6;732:140-51
pubmed: 7978787
Periodontol 2000. 2018 Feb;76(1):131-149
pubmed: 29193331
J Periodontol. 2018 Jun;89 Suppl 1:S74-S84
pubmed: 29926944
Eur J Cell Biol. 1997 Oct;74(2):111-22
pubmed: 9352216
Clin Diagn Lab Immunol. 1999 May;6(3):437-9
pubmed: 10225852
Adv Dent Res. 1998 Nov;12(2):114-8
pubmed: 9972133
Anticancer Drugs. 2002 Mar;13(3):245-54
pubmed: 11984068
J Med Chem. 2002 Aug 15;45(17):3721-38
pubmed: 12166945
Oral Dis. 2014 Sep;20(6):538-50
pubmed: 23849049
Cancer Res. 2000 Jun 1;60(11):2949-54
pubmed: 10850442