Raman image-activated cell sorting.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
10 07 2020
Historique:
received: 11 02 2020
accepted: 18 06 2020
entrez: 12 7 2020
pubmed: 12 7 2020
medline: 1 9 2020
Statut: epublish

Résumé

The advent of image-activated cell sorting and imaging-based cell picking has advanced our knowledge and exploitation of biological systems in the last decade. Unfortunately, they generally rely on fluorescent labeling for cellular phenotyping, an indirect measure of the molecular landscape in the cell, which has critical limitations. Here we demonstrate Raman image-activated cell sorting by directly probing chemically specific intracellular molecular vibrations via ultrafast multicolor stimulated Raman scattering (SRS) microscopy for cellular phenotyping. Specifically, the technology enables real-time SRS-image-based sorting of single live cells with a throughput of up to ~100 events per second without the need for fluorescent labeling. To show the broad utility of the technology, we show its applicability to diverse cell types and sizes. The technology is highly versatile and holds promise for numerous applications that are previously difficult or undesirable with fluorescence-based technologies.

Identifiants

pubmed: 32651381
doi: 10.1038/s41467-020-17285-3
pii: 10.1038/s41467-020-17285-3
pmc: PMC7351993
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3452

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Auteurs

Nao Nitta (N)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.
Japan Science and Technology Agency, Kawaguchi, 332-0012, Japan.
CYBO, Tokyo, 101-0022, Japan.

Takanori Iino (T)

Department of Electrical Engineering and Information Systems, The University of Tokyo, Tokyo, 113-8656, Japan.

Akihiro Isozaki (A)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.
Kanagawa Institute of Industrial Science and Technology, 705-1 Shimoimaizumi, Ebina, Kanagawa, 243-0435, Japan.

Mai Yamagishi (M)

Department of Biological Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.

Yasutaka Kitahama (Y)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.

Shinya Sakuma (S)

Department of Micro-Nano Mechanical Science and Engineering, Nagoya University, Nagoya, 464-8601, Japan.

Yuta Suzuki (Y)

Department of Electrical Engineering and Information Systems, The University of Tokyo, Tokyo, 113-8656, Japan.

Hiroshi Tezuka (H)

Department of Creative Informatics, The University of Tokyo, Tokyo, 113-0033, Japan.

Minoru Oikawa (M)

Natural Sciences Cluster, Sciences Unit, Kochi University, Kochi, 780-8520, Japan.

Fumihito Arai (F)

Department of Micro-Nano Mechanical Science and Engineering, Nagoya University, Nagoya, 464-8601, Japan.

Takuya Asai (T)

Department of Electrical Engineering and Information Systems, The University of Tokyo, Tokyo, 113-8656, Japan.

Dinghuan Deng (D)

Department of Electrical Engineering and Information Systems, The University of Tokyo, Tokyo, 113-8656, Japan.

Hideya Fukuzawa (H)

Graduate School of Biostudies, Kyoto University, Kyoto, 606-8502, Japan.

Misa Hase (M)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.

Tomohisa Hasunuma (T)

Graduate School of Science, Technology and Innovation, Kobe University, Kobe, 657-8501, Japan.
Engineering Biology Research Center, Kobe University, Kobe, 657-8501, Japan.

Takeshi Hayakawa (T)

Department of Precision Mechanics, Chuo University, Tokyo, 192-0393, Japan.

Kei Hiraki (K)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.

Kotaro Hiramatsu (K)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.

Yu Hoshino (Y)

Department of Chemical Engineering, Kyushu University, Fukuoka, 819-0395, Japan.

Mary Inaba (M)

Department of Creative Informatics, The University of Tokyo, Tokyo, 113-0033, Japan.

Yuki Inoue (Y)

Department of Electrical Engineering and Information Systems, The University of Tokyo, Tokyo, 113-8656, Japan.

Takuro Ito (T)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.
Japan Science and Technology Agency, Kawaguchi, 332-0012, Japan.

Masataka Kajikawa (M)

Graduate School of Biostudies, Kyoto University, Kyoto, 606-8502, Japan.

Hiroshi Karakawa (H)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.

Yusuke Kasai (Y)

Department of Micro-Nano Mechanical Science and Engineering, Nagoya University, Nagoya, 464-8601, Japan.

Yuichi Kato (Y)

Engineering Biology Research Center, Kobe University, Kobe, 657-8501, Japan.

Hirofumi Kobayashi (H)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.

Cheng Lei (C)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.
Institute of Technological Sciences, Wuhan University, 430072, Wuhan, China.

Satoshi Matsusaka (S)

Department of Clinical Research and Regional Innovation, University of Tsukuba, Ibaraki, 305-8577, Japan.
Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan.

Hideharu Mikami (H)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.

Atsuhiro Nakagawa (A)

Department of Neurosurgery, Graduate School of Medicine, Tohoku University, Sendai, 980-8577, Japan.

Keiji Numata (K)

Biomacromolecules Research Team, RIKEN Center for Sustainable Resource Science, Wako, 351-0198, Japan.

Tadataka Ota (T)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.

Takeichiro Sekiya (T)

Department of Electrical Engineering and Information Systems, The University of Tokyo, Tokyo, 113-8656, Japan.

Kiyotaka Shiba (K)

Division of Protein Engineering, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan.

Yoshitaka Shirasaki (Y)

Department of Biological Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.

Nobutake Suzuki (N)

Department of Biological Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.

Shunji Tanaka (S)

Department of Electrical Engineering and Information Systems, The University of Tokyo, Tokyo, 113-8656, Japan.

Shunnosuke Ueno (S)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.

Hiroshi Watarai (H)

Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.

Takashi Yamano (T)

Graduate School of Biostudies, Kyoto University, Kyoto, 606-8502, Japan.

Masayuki Yazawa (M)

Department of Rehabilitation and Regenerative Medicine and Pharmacology, Columbia University, New York, 10032, USA.

Yusuke Yonamine (Y)

Research Institute for Electronic Science, Hokkaido University, Sapporo, 001-0021, Japan.

Dino Di Carlo (D)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.
Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA.
Department of Mechanical Engineering, University of California, Los Angeles, CA, 90095, USA.
California NanoSystems Institute, University of California, Los Angeles, CA, 90095, USA.

Yoichiroh Hosokawa (Y)

Division of Materials Science, Nara Institute of Science and Technology, Ikoma, 630-0192, Japan.

Sotaro Uemura (S)

Department of Biological Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.

Takeaki Sugimura (T)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan.
Japan Science and Technology Agency, Kawaguchi, 332-0012, Japan.
CYBO, Tokyo, 101-0022, Japan.

Yasuyuki Ozeki (Y)

Department of Electrical Engineering and Information Systems, The University of Tokyo, Tokyo, 113-8656, Japan.

Keisuke Goda (K)

Department of Chemistry, The University of Tokyo, Tokyo, 113-0033, Japan. goda@chem.s.u-tokyo.ac.jp.
Japan Science and Technology Agency, Kawaguchi, 332-0012, Japan. goda@chem.s.u-tokyo.ac.jp.
Institute of Technological Sciences, Wuhan University, 430072, Wuhan, China. goda@chem.s.u-tokyo.ac.jp.
Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA. goda@chem.s.u-tokyo.ac.jp.

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