Extrapulmonary manifestations of COVID-19.
Adaptive Immunity
/ physiology
Betacoronavirus
/ pathogenicity
COVID-19
Coronavirus Infections
/ diagnosis
Disease Progression
Endothelium, Vascular
/ pathology
Humans
Inflammation
/ etiology
Organ Specificity
Pandemics
Pneumonia, Viral
/ diagnosis
Renin-Angiotensin System
/ physiology
SARS-CoV-2
Thrombosis
/ etiology
Virus Internalization
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
29
04
2020
accepted:
05
06
2020
pubmed:
12
7
2020
medline:
23
7
2020
entrez:
12
7
2020
Statut:
ppublish
Résumé
Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. In addition, endothelial damage and thromboinflammation, dysregulation of immune responses, and maladaptation of ACE2-related pathways might all contribute to these extrapulmonary manifestations of COVID-19. Here we review the extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19 to aid clinicians and scientists in recognizing and monitoring the spectrum of manifestations, and in developing research priorities and therapeutic strategies for all organ systems involved.
Identifiants
pubmed: 32651579
doi: 10.1038/s41591-020-0968-3
pii: 10.1038/s41591-020-0968-3
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1017-1032Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL122526
Pays : United States
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