AKI: an increasingly recognized risk factor for CKD development and progression.
AKD
AKI
CKD
Mechanisms
Renal fibrosis
Journal
Journal of nephrology
ISSN: 1724-6059
Titre abrégé: J Nephrol
Pays: Italy
ID NLM: 9012268
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
14
04
2020
accepted:
26
06
2020
pubmed:
12
7
2020
medline:
19
8
2021
entrez:
12
7
2020
Statut:
ppublish
Résumé
Acute kidney injury (AKI) is an increasing health burden with high morbidity and mortality rates worldwide. AKI is a risk factor for chronic kidney disease (CKD) development and progression to end stage renal disease (ESRD). Rapid action is required to find treatment options for AKI, plus to anticipate the development of CKD and other complications. Therefore, it is essential to understand the pathophysiology of AKI to CKD transition. Over the last several years, research has revealed maladaptive repair to be an interplay of cell death, endothelial dysfunction, tubular epithelial cell senescence, inflammatory processes and more-terminating in fibrosis. Various pathological mechanisms have been discovered and reveal targets for potential interventions. Furthermore, there have been clinical efforts measures for AKI prevention and progression including the development of novel biomarkers and prediction models. In this review, we provide an overview of pathophysiological mechanisms involved in kidney fibrosis. Furthermore, we discuss research gaps and promising therapeutic approaches for AKI to CKD progression.
Identifiants
pubmed: 32651850
doi: 10.1007/s40620-020-00793-2
pii: 10.1007/s40620-020-00793-2
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1171-1187Subventions
Organisme : Dr. Werner Jackstädt-Stiftung
ID : S 134-10.117
Organisme : Italian Ministry of Education, University and Research (MIUR) program
ID : AGING Project
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