Perioperative Management of Elderly patients (PriME): recommendations from an Italian intersociety consensus.

Analgesia Anesthesia Comprehensive geriatric assessment Frail older Older patients Perioperative care Surgery

Journal

Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 03 03 2020
accepted: 03 06 2020
pubmed: 12 7 2020
medline: 1 12 2020
entrez: 12 7 2020
Statut: ppublish

Résumé

Surgical outcomes in geriatric patients may be complicated by factors such as multiple comorbidities, low functional performance, frailty, reduced homeostatic capacity, and cognitive impairment. An integrated multidisciplinary approach to management is, therefore, essential in this population, but at present, the use of such an approach is uncommon. The Perioperative Management of Elderly patients (PriME) project has been established to address this issue. To develop evidence-based recommendations for the integrated care of geriatric surgical patients. A 14-member Expert Task Force of surgeons, anesthetists, and geriatricians was established to develop evidence-based recommendations for the pre-, intra-, and postoperative care of hospitalized older patients (≥ 65 years) undergoing elective surgery. A modified Delphi approach was used to achieve consensus, and the strength of recommendations and quality of evidence was rated using the U.S. Preventative Services Task Force criteria. A total of 81 recommendations were proposed, covering preoperative evaluation and care (30 items), intraoperative management (19 items), and postoperative care and discharge (32 items). These recommendations should facilitate the multidisciplinary management of older surgical patients, integrating the expertise of the surgeon, the anesthetist, the geriatrician, and other specialists and health care professionals (where available) as needed. These roles may vary according to the phase and setting of care and the patient's conditions.

Sections du résumé

BACKGROUND BACKGROUND
Surgical outcomes in geriatric patients may be complicated by factors such as multiple comorbidities, low functional performance, frailty, reduced homeostatic capacity, and cognitive impairment. An integrated multidisciplinary approach to management is, therefore, essential in this population, but at present, the use of such an approach is uncommon. The Perioperative Management of Elderly patients (PriME) project has been established to address this issue.
AIMS OBJECTIVE
To develop evidence-based recommendations for the integrated care of geriatric surgical patients.
METHODS METHODS
A 14-member Expert Task Force of surgeons, anesthetists, and geriatricians was established to develop evidence-based recommendations for the pre-, intra-, and postoperative care of hospitalized older patients (≥ 65 years) undergoing elective surgery. A modified Delphi approach was used to achieve consensus, and the strength of recommendations and quality of evidence was rated using the U.S. Preventative Services Task Force criteria.
RESULTS RESULTS
A total of 81 recommendations were proposed, covering preoperative evaluation and care (30 items), intraoperative management (19 items), and postoperative care and discharge (32 items).
CONCLUSIONS CONCLUSIONS
These recommendations should facilitate the multidisciplinary management of older surgical patients, integrating the expertise of the surgeon, the anesthetist, the geriatrician, and other specialists and health care professionals (where available) as needed. These roles may vary according to the phase and setting of care and the patient's conditions.

Identifiants

pubmed: 32651902
doi: 10.1007/s40520-020-01624-x
pii: 10.1007/s40520-020-01624-x
pmc: PMC7508736
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1647-1673

Commentaires et corrections

Type : ErratumIn

Références

Demographic Indicators (2019) Estimates for the year 2018. Italian National Institute of Statistics (Istituto Nazionale di Statistica; Istat). https://www.istat.it/it/files//2019/02/Indicatoridemografici2018_EN.pdf . Accessed 26 Feb 2020
Moyet J, Deschasse G, Marquant B et al (2019) Which is the optimal orthogeriatric care model to prevent mortality of elderly subjects post hip fractures? A systematic review and meta-analysis based on current clinical practice. Int Orthop 43:1449–1454
pubmed: 29691612
United States Preventive Services Task Force. Grade definitions. https://www.uspreventiveservicestaskforce.org/Page/Name/grade-definitions . Accessed 26 Feb 2020
Bettelli G (2018) Preoperative evaluation of the elderly surgical patient and anesthesia challenges in the XXI century. Aging Clin Exp Res 30:229–235
pubmed: 29446038
Rubenstein LZ (2004) Joseph T. Freeman award lecture: comprehensive geriatric assessment: from miracle to reality. J Gerontol Ser A Biol Sci Med Sci 59:473–477
Feng MA, McMillan DT, Crowell K et al (2015) Geriatric assessment in surgical oncology: a systematic review. J Surg Res 193:265–272
pubmed: 25091339
Partridge JS, Harari D, Martin FC et al (2014) The impact of pre-operative comprehensive geriatric assessment on postoperative outcomes in older patients undergoing scheduled surgery: a systematic review. Anaesthesia 69(Suppl 1):8–16
pubmed: 24303856
Ellis G, Gardner M, Tsiachristas A et al (2017) Comprehensive geriatric assessment for older adults admitted to hospital. Cochrane Database Syst Rev 9:Cd006211
pubmed: 28898390
Pilotto A, Cella A, Pilotto A et al (2017) Three decades of comprehensive geriatric assessment: evidence coming from different healthcare settings and specific clinical conditions. J Am Med Dir Assoc 18:192.e1–e11
Fried LP, Ferrucci L, Darer J et al (2004) Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol Ser A Biol Sci Med Sci 59:255–263
Barbagallo M, Dominguez LJ, Cucinotta D (2018) The place of frailty and vulnerability in the surgical risk assessment: should we move from complexity to simplicity? Aging Clin Exp Res 30:237–239
pubmed: 29336006
Chan SP, Ip KY, Irwin MG (2019) Peri-operative optimisation of elderly and frail patients: a narrative review. Anaesthesia 74(Suppl 1):80–89
pubmed: 30604415
Chow WB, Rosenthal RA, Merkow RP et al (2012) Optimal preoperative assessment of the geriatric surgical patient: a best practices guideline from the American College of Surgeons National Surgical Quality Improvement Program and the American Geriatrics Society. J Am Coll Surg 215:453–466
pubmed: 22917646
Robinson TN, Walston JD, Brummel NE et al (2015) Frailty for surgeons: review of a National Institute on Aging Conference on Frailty for Specialists. J Am Coll Surg 221:1083–1092
pubmed: 26422746 pmcid: 4673051
Rolfson DB, Majumdar SR, Tsuyuki RT et al (2006) Validity and reliability of the Edmonton Frail Scale. Age Ageing 35:526–529
pubmed: 16757522 pmcid: 5955195
Kumar C, Salzman B, Colburn JL (2018) Preoperative assessment in older adults: a comprehensive approach. Am Fam Phy 98:214–220
Batchelor TJP, Rasburn NJ, Abdelnour-Berchtold E et al (2019) Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS(R)) Society and the European Society of Thoracic Surgeons (ESTS). Eur J Cardiothorac Surg 55:91–115
pubmed: 30304509
Li C, Carli F, Lee L (2013) Impact of a trimodal prehabilitation program on functional recovery after colorectal cancer surgery: a pilot study. Surg Endosc 27:1072–1082
pubmed: 23052535
Levett DZH, Jack S, Swart M et al (2018) Perioperative cardiopulmonary exercise testing (CPET): consensus clinical guidelines on indications, organization, conduct, and physiological interpretation. Br J Anaesth 120:484–500
pubmed: 29452805
Tinetti ME, Baker DI, McAvay G et al (1994) A multifactorial intervention to reduce the risk of falling among elderly people living in the community. N Engl J Med 331:821–827
pubmed: 8078528
Jones TS, Dunn CL, Wu DS et al (2013) Relationship between asking an older adult about falls and surgical outcomes. JAMA Surg 148:1132–1138
pubmed: 24108317 pmcid: 4222577
Summary of the Updated American Geriatrics Society/British Geriatrics Society clinical practice guideline for prevention of falls in older persons (2011) J Am Geriatr Soc 59:148–157
Whitson HE, Cronin-Golomb A, Cruickshanks KJ et al (2018) American Geriatrics Society and National Institute on Aging Bench-to-Bedside Conference: sensory impairment and cognitive decline in older adults. J Am Geriatr Soc 66:2052–2058
pubmed: 30248173 pmcid: 6410371
Gajdos C, Kile D, Hawn MT et al (2015) The significance of preoperative impaired sensorium on surgical outcomes in nonemergent general surgical operations. JAMA Surg 150:30–36
pubmed: 25409305
Inouye SK, Bogardus ST Jr, Charpentier PA et al (1999) A multicomponent intervention to prevent delirium in hospitalized older patients. N Eng J Med 340:669–676
Bacigalupo I, Mayer F, Lacorte E et al (2018) A systematic review and meta-analysis on the prevalence of dementia in Europe: estimates from the highest-quality studies adopting the DSM IV diagnostic criteria. J Alzheimer's Dis 66:1471–1481
Limongi F, Siviero P, Noale M et al (2017) Prevalence and conversion to dementia of mild cognitive impairment in an elderly Italian population. Aging Clin Exp Res 29:361–370
pubmed: 28353219
Gauthier S, Reisberg B, Zaudig M et al (2006) Mild cognitive impairment. Lancet 367:1262–1270
pubmed: 16631882
Petersen RC (2011) Clinical practice. Mild cognitive impairment. N Engl J Med 364:2227–2234
pubmed: 21651394
Plassman BL, Langa KM, Fisher GG et al (2008) Prevalence of cognitive impairment without dementia in the United States. Ann Intern Med 148:427–434
pubmed: 18347351 pmcid: 2670458
Crosby G, Culley DJ, Hyman BT (2011) Preoperative cognitive assessment of the elderly surgical patient: a call for action. Anesthesiology 114:1265–1268
pubmed: 21490501 pmcid: 3123886
Oresanya LB, Lyons WL, Finlayson E (2014) Preoperative assessment of the older patient: a narrative review. JAMA 311:2110–2120
pubmed: 24867014
Robinson TN, Wu DS, Pointer LF et al (2012) Preoperative cognitive dysfunction is related to adverse postoperative outcomes in the elderly. J Am Coll Surg 215:12–18
pubmed: 22626912 pmcid: 3383613
Bettelli G (2011) Preoperative evaluation in geriatric surgery: comorbidity, functional status and pharmacological history. Minerva Anestesiol 77:637–646
pubmed: 21617627
Wei J, Zeng L, Li S et al (2019) Relationship between comorbidities and treatment decision-making in elderly hip fracture patients. Aging Clin Exp Res 31:1735–1741
pubmed: 30993661 pmcid: 6825646
Griffiths R, Beech F, Brown A et al (2014) Peri-operative care of the elderly 2014: Association of Anaesthetists of Great Britain and Ireland. Anaesthesia 69(Suppl 1):81–98
pubmed: 24303864
Fleisher LA, Fleischmann KE, Auerbach AD et al (2014) 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 130:2215–2245
pubmed: 25085962
Freeman WK, Gibbons RJ (2009) Perioperative cardiovascular assessment of patients undergoing noncardiac surgery. Mayo Clin Proc 84:79–90
pubmed: 19121258 pmcid: 2664575
Lee TH, Marcantonio ER, Mangione CM et al (1999) Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation 100:1043–1049
pubmed: 10477528
Alrezk R, Jackson N, Al Rezk M et al (2017) Derivation and validation of a geriatric-sensitive perioperative cardiac risk index. J Am Heart Assoc 6:e006648
pubmed: 29146612 pmcid: 5721761
Bilimoria KY, Liu Y, Paruch JL et al (2013) Development and evaluation of the universal ACS NSQIP surgical risk calculator: a decision aid and informed consent tool for patients and surgeons. J Am Coll Surg 217:833–842
pubmed: 24055383 pmcid: 3805776
Markovic DZ, Jevtovic-Stoimenov T, Cosic V et al (2018) Addition of biomarker panel improves prediction performance of American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) calculator for cardiac risk assessment of elderly patients preparing for major non-cardiac surgery: a pilot study. Aging Clin Exp Res 30:419–431
pubmed: 28752477
Kozek-Langenecker S, Fenger-Eriksen C, Thienpont E et al (2018) European guidelines on perioperative venous thromboembolism prophylaxis: surgery in the elderly. Eur J Anaesth 35:116–122
Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS—an observational study in 29 countries (2017) Eur J Anaesth 34:492–507
Perilli V, Aceto P, Ancona P et al (2018) Role of surgical setting and patients-related factors in predicting the occurrence of postoperative pulmonary complications after abdominal surgery. Eur Rev Med Pharmacol Sci 22:547–550
pubmed: 29424916
Smetana GW (2003) Preoperative pulmonary assessment of the older adult. Clin Geriatr Med 19:35–55
pubmed: 12735114
Canet J, Gallart L, Gomar C et al (2010) Prediction of postoperative pulmonary complications in a population-based surgical cohort. Anesthesiology 113:1338–1350
pubmed: 21045639
Mazo V, Sabate S, Canet J et al (2014) Prospective external validation of a predictive score for postoperative pulmonary complications. Anesthesiology 121:219–231
pubmed: 24901240
Katsura M, Kuriyama A, Takeshima T et al (2015) Preoperative inspiratory muscle training for postoperative pulmonary complications in adults undergoing cardiac and major abdominal surgery. Cochrane Database Syst Rev 2015:Cd010356
Boden I, Skinner EH, Browning L et al (2018) Preoperative physiotherapy for the prevention of respiratory complications after upper abdominal surgery: pragmatic, double blinded, multicentre randomised controlled trial. BMJ (Clin Res) 360:j5916
Musallam KM, Tamim HM, Richards T et al (2011) Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet 378:1396–1407
pubmed: 21982521
Nissenson AR, Goodnough LT, Dubois RW (2003) Anemia: not just an innocent bystander? Arch Int Med 163:1400–1404
Munoz M, Acheson AG, Auerbach M et al (2017) International consensus statement on the peri-operative management of anaemia and iron deficiency. Anaesthesia 72:233–247
pubmed: 27996086
Goodnough LT, Schrier SL (2014) Evaluation and management of anemia in the elderly. Am J Hematol 89:88–96
pubmed: 24122955 pmcid: 4289144
Mueller MM, Van Remoortel H, Meybohm P et al (2019) Patient Blood management: recommendations from the 2018 Frankfurt Consensus Conference. JAMA 321:983–997
pubmed: 30860564
Spahn DR, Theusinger OM, Hofmann A (2012) Patient blood management is a win-win: a wake-up call. Br J Anaesth 108:889–892
pubmed: 22593125
Franchini M, Marano G, Veropalumbo E et al (2019) Patient blood management: a revolutionary approach to transfusion medicine. Blood Transfus 17:191–195
pubmed: 31246561 pmcid: 6596379
Cinnella G, Pavesi M, De Gasperi A et al (2019) Clinical standards for patient blood management and perioperative hemostasis and coagulation management. Position Paper of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI). Minerva Anestesiol 85:635–664
pubmed: 30762323
Franchini M, Marano G, Mengoli C et al (2017) Red blood cell transfusion policy: a critical literature review. Blood Transfus 15:307–317
pubmed: 28661855 pmcid: 5490725
Wirtz D, Kohlhof H (2019) The geriatric patient: special aspects of peri-operative management. EFORT Open Rev 4:240–247
pubmed: 31210966 pmcid: 6549215
Kim S, Brooks AK, Groban L (2015) Preoperative assessment of the older surgical patient: honing in on geriatric syndromes. Clin Interv Aging 10:13–27
pubmed: 25565783
van Stijn MF, Korkic-Halilovic I, Bakker MS et al (2013) Preoperative nutrition status and postoperative outcome in elderly general surgery patients: a systematic review. J Parenter Enteral Nutr 37:37–43
Corish CA (2001) Pre-operative nutritional assessment in the elderly. J Nutr Health Aging 5:49–59
pubmed: 11250670
Kaiser MJ, Bauer JM, Ramsch C et al (2010) Frequency of malnutrition in older adults: a multinational perspective using the mini nutritional assessment. J Am Geriatr Soc 58:1734–1738
pubmed: 20863332
Weimann A, Braga M, Carli F et al (2017) ESPEN guideline: clinical nutrition in surgery. Clin Nutr 36:623–650
pubmed: 28385477
Arozullah AM, Daley J, Henderson WG, Khuri SF (2000) Multifactorial risk index for predicting postoperative respiratory failure in men after major noncardiac surgery. The National Veterans Administration Surgical Quality Improvement Program. Ann Surg 232:242–253
pubmed: 10903604 pmcid: 1421137
Khuri SF, Daley J, Henderson W et al (1997) Risk adjustment of the postoperative mortality rate for the comparative assessment of the quality of surgical care: results of the National Veterans Affairs Surgical Risk Study. J Am Coll Surg 185:315–327
pubmed: 9328380
Tommasino T (2017) Diagnosis and treatment of nutritional deficits. In: Bettelli G (ed) Perioperative care of the elderly. Clinical and organizational aspects. Cambridge University Press, Cambridge, pp 90–96
Finlayson E, Maselli J, Steinman MA et al (2011) Inappropriate medication use in older adults undergoing surgery: a national study. J Am Geriatr Soc 59:2139–2144
pubmed: 21883113 pmcid: 3959950
Aldecoa C, Bettelli G, Bilotta F et al (2017) European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium. Eur J Anaesth 34:192–214
Gorup E, Rifel J, Petek Ster M (2018) Anticholinergic burden and most common anticholinergic-acting medicines in older general practice patients. Zdr Varst 57:140–147
pubmed: 29983780 pmcid: 6032175
Mohanty S, Rosenthal RA, Russell MM et al (2016) Optimal perioperative management of the geriatric patient: a best practices guideline from the American College of Surgeons NSQIP and the American Geriatrics Society. J Am Coll Surg 222:930–947
pubmed: 27049783
Zhang X, Zhou S, Pan K et al (2017) Potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria. Clin Interv Aging 12:1697–1703
pubmed: 29066875 pmcid: 5644572
O'Mahony D, O'Sullivan D, Byrne S et al (2015) STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing 44:213–218 (Published correction appears in Age Ageing 2018;47:489)
pubmed: 25324330
Association AP, Task Force DSM (2013) Diagnostic and statistical manual of mental disorders: DSM-5™, 5th edn. American Psychiatric Publishing, Arlington
World Health Organization (2016) International statistical classification of diseases and related health problems 10th revision. https://icd.who.int/browse10/2016/en . Accessed 26 Feb 2020
Scottish Intercollegiate Guidelines Network (SIGN) (2019) Risk reduction and management of delirium: a national clinical guideline. https://www.sign.ac.uk/assets/sign157.pdf . Accessed 26 Feb 2020
National Institute for Health and Care Excellence (NICE) (2019) Delirium: prevention, diagnosis and management. Clinical guideline [CG103]. https://www.nice.org.uk/guidance/cg103 . Accessed 26 Feb 2020
LaMantia MA, Messina FC, Hobgood CD et al (2014) Screening for delirium in the emergency department: a systematic review. Ann Emerg Med 63:551–560
pubmed: 24355431
Neto AS, Nassar AP Jr, Cardoso SO et al (2012) Delirium screening in critically ill patients: a systematic review and meta-analysis. Crit Care Med 40:1946–1951
pubmed: 22610196
Bettelli G, Neuner B (2017) Postoperative delirium: a preventable complication in the elderly surgical patient. Monaldi Arch Chest Dis 87:842
pubmed: 28967724
Neuner B, Hadzidiakos D, Bettelli G (2018) Pre- and postoperative management of risk factors for postoperative delirium: who is in charge and what is its essence? Aging Clin Exp Res 30:245–248
pubmed: 29353441
O'Sullivan D, Brady N, Manning E et al (2018) Validation of the 6-Item Cognitive Impairment Test and the 4AT test for combined delirium and dementia screening in older Emergency Department attendees. Age Ageing 47:61–68
pubmed: 28985260
Hendry K, Quinn TJ, Evans J et al (2016) Evaluation of delirium screening tools in geriatric medical inpatients: a diagnostic test accuracy study. Age Ageing 45:832–837
pubmed: 27503794
Shafer SL (2000) The pharmacology of anesthetic drugs in elderly patients. Anesthesiol Clin N Am 18:1–29
Defrin R, Amanzio M, de Tommaso M et al (2015) Experimental pain processing in individuals with cognitive impairment: current state of the science. Pain 156:1396–1408
pubmed: 26181216
Bettelli G (2017) Safety in the operating room: special needs of geriatric patients. In: Bettelli G (ed) Perioperative care of the elderly. Clinical and organizational aspects. Cambridge University Press, Cambridge, pp 120–124
Horgas AL, Nichols AL, Schapson CA et al (2007) Assessing pain in persons with dementia: relationships among the non-communicative patient's pain assessment instrument, self-report, and behavioral observations. Pain Manag Nurs 8:77–85
pubmed: 17544127
Warden V, Hurley AC, Volicer L (2003) Development and psychometric evaluation of the Pain Assessment in Advanced Dementia (PAINAD) scale. J Am Med Dir Assoc 4:9–15
pubmed: 12807591
Kothari A, Phillips S, Bretl T et al (2011) Components of geriatric assessments predict thoracic surgery outcomes. J Surg Res 166:5–13
pubmed: 20828735
Duivenvoorden T, Vissers MM, Verhaar JA et al (2013) Anxiety and depressive symptoms before and after total hip and knee arthroplasty: a prospective multicentre study. Osteoarthr Cartil 21:1834–1840
pubmed: 24012622
Leung JM, Sands LP, Mullen EA et al (2005) Are preoperative depressive symptoms associated with postoperative delirium in geriatric surgical patients? J Gerontol Ser A Biol Sci Med Sci 60:1563–1568
Burke WJ, Roccaforte WH, Wengel SP (1991) The short form of the Geriatric Depression Scale: a comparison with the 30-item form. J Geriatr Psychiatry Neurol 4:173–178
pubmed: 1953971
Kenig J, Olszewska U, Zychiewicz B et al (2015) Cumulative deficit model of geriatric assessment to predict the postoperative outcomes of older patients with solid abdominal cancer. J Geriatr Oncol 6:370–379
pubmed: 26144556
Guay J, Choi P, Suresh S et al (2014) Neuraxial blockade for the prevention of postoperative mortality and major morbidity: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev 2014:Cd010108
pmcid: 7087466
Kruijt Spanjer MR, Bakker NA, Absalom AR (2011) Pharmacology in the elderly and newer anaesthesia drugs. Best Pract Res Clin Anaesthesiol 25:355–365
pubmed: 21925401
Steinmetz J, Rasmussen LS (2010) The elderly and general anesthesia. Minerva Anestesiol 76:745–752
pubmed: 20820153
Tommasino C, Corcione A (2018) Anesthesia for the elderly patient. In: Crucitti A (ed) Surgical management of elderly patients. Springer International Publishing, New York, pp 9–29
Phillips AT, Deiner S, Mo Lin H et al (2015) Propofol use in the elderly population: prevalence of overdose and association with 30-day mortality. Clin Ther 37:2676–2685
pubmed: 26548320 pmcid: 5864105
Schnider TW, Minto CF, Shafer SL et al (1999) The influence of age on propofol pharmacodynamics. Anesthesiology 90:1502–1516
pubmed: 10360845
National Institute of Health and Care Excellence (NICE) (2012) Depth of anaesthesia monitors—Bispectral Index (BIS), E-Entropy and Narcotrend-Compact M. Diagnostics guidance [DG6]. https://www.nice.org.uk/guidance/dg6 . Accessed 26 Feb 2020
Brioni JD, Varughese S, Ahmed R et al (2017) A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics. J Anesth 31:764–778
pubmed: 28585095 pmcid: 5640726
Nickalls RW, Mapleson WW (2003) Age-related iso-MAC charts for isoflurane, sevoflurane and desflurane in man. Br J Anaesth 91:170–174
pubmed: 12878613
Chan MT, Cheng BC, Lee TM et al (2013) BIS-guided anesthesia decreases postoperative delirium and cognitive decline. J Neurosurg Anesthesiol 25:33–42
pubmed: 23027226
Radtke FM, Franck M, Lendner J et al (2013) Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction. Br J Anaesth 110(Suppl 1):i98–i105
pubmed: 23539235
Schneider G, Sebel PS (1997) Monitoring depth of anaesthesia. Eur J Anaesth 15(Supplement):21–28
Hajat Z, Ahmad N, Andrzejowski J (2017) The role and limitations of EEG-based depth of anaesthesia monitoring in theatres and intensive care. Anaesthesia 72(Suppl 1):38–47
pubmed: 28044337
Zorrilla-Vaca A, Healy RJ, Wu CL et al (2017) Relation between bispectral index measurements of anesthetic depth and postoperative mortality: a meta-analysis of observational studies. Can J Anaesth 64:597–607
pubmed: 28361391
Aceto P, Lai C, Perilli V et al (2013) Stress-related biomarkers of dream recall and implicit memory under anaesthesia. Anaesthesia 68:1141–1147
pubmed: 23952901
Aceto P, Perilli V, Lai C et al (2013) Update on post-traumatic stress syndrome after anesthesia. Eur Rev Med Pharmacol Sci 17:1730–1737
pubmed: 23852895
Sieber FE, Neufeld KJ, Gottschalk A et al (2018) Effect of depth of sedation in older patients undergoing hip fracture repair on postoperative delirium: the STRIDE randomized clinical trial. JAMA Surg 153:987–995
pubmed: 30090923 pmcid: 6583071
Cope TM, Hunter JM (2003) Selecting neuromuscular-blocking drugs for elderly patients. Drugs Aging 20:125–140
pubmed: 12534313
Lee LA, Athanassoglou V, Pandit JJ (2016) Neuromuscular blockade in the elderly patient. J Pain Res 9:437–444
pubmed: 27382330 pmcid: 4918890
Biro P, Paul G, Dahan A et al (2019) Proposal for a revised classification of the depth of neuromuscular block and suggestions for further development in neuromuscular monitoring. Anesth Analg 128:1361–1363
pubmed: 31094813
Cedborg AI, Sundman E, Boden K et al (2014) Pharyngeal function and breathing pattern during partial neuromuscular block in the elderly: effects on airway protection. Anesthesiology 120:312–325
pubmed: 24162461
Young WL, Matteo RS, Ornstein E (1988) Duration of action of neostigmine and pyridostigmine in the elderly. Anesth Analg 67:775–778
pubmed: 3394965
Stone JG, Matteo RS, Ornstein E et al (1995) Aging alters the pharmacokinetics of pyridostigmine. Anesth Analg 81:773–776
pubmed: 7574009
Matteo RS, Young WL, Ornstein E et al (1990) Pharmacokinetics and pharmacodynamics of edrophonium in elderly surgical patients. Anesth Analg 71:334–339
pubmed: 2169210
McDonagh DL, Benedict PE, Kovac AL et al (2011) Efficacy, safety, and pharmacokinetics of sugammadex for the reversal of rocuronium-induced neuromuscular blockade in elderly patients. Anesthesiology 114:318–329
pubmed: 21239968
Carron M, Zarantonello F, Tellaroli P et al (2016) Efficacy and safety of sugammadex compared to neostigmine for reversal of neuromuscular blockade: a meta-analysis of randomized controlled trials. J Clin Anesth 35:1–12
pubmed: 27871504
Muramatsu T, Isono S, Ishikawa T et al (2018) Differences of recovery from rocuronium-induced deep paralysis in response to small doses of sugammadex between elderly and nonelderly patients. Anesthesiology 129:901–911
pubmed: 30199419
Xu H, Xu G, Ren C et al (2019) Effect of forced-air warming system in prevention of postoperative hypothermia in elderly patients: a prospective controlled trial. Medicine 98:e15895
pubmed: 31145350 pmcid: 6708676
Ma H, Lai B, Dong S et al (2017) Warming infusion improves perioperative outcomes of elderly patients who underwent bilateral hip replacement. Medicine 96:e6490
pubmed: 28353593 pmcid: 5380277
Miller TE, Myles PS (2019) Perioperative fluid therapy for major surgery. Anesthesiology 130:825–832
pubmed: 30789364
Feldheiser A, Aziz O, Baldini G et al (2016) Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for anaesthesia practice. Acta Anaesthesiol Scand 60:289–334
pubmed: 26514824
Gupta R, Gan TJ (2016) Peri-operative fluid management to enhance recovery. Anaesthesia 71(Suppl 1):40–45
pubmed: 26620145
Myles PS, Bellomo R, Corcoran T et al (2018) Restrictive versus liberal fluid therapy for major abdominal surgery. N Engl J Med 378:2263–2274
pubmed: 29742967
Giglio M, Manca F, Dalfino L et al (2016) Perioperative hemodynamic goal-directed therapy and mortality: a systematic review and meta-analysis with meta-regression. Minerva Anestesiol 82:1199–1213
pubmed: 27075210
Brienza N, Biancofiore G, Cavaliere F et al (2019) Clinical guidelines for perioperative hemodynamic management of non cardiac surgical adult patients. Minerva Anestesiol 85:1315–1333
pubmed: 31213042
Greinacher A, Fendrich K, Brzenska R et al (2011) Implications of demographics on future blood supply: a population-based cross-sectional study. Transfusion 51:702–709
pubmed: 20849411
Vaglio S, Gentili S, Marano G et al (2017) The Italian Regulatory Guidelines for the implementation of Patient Blood Management. Blood Transfus 15:325–328
pubmed: 28488975 pmcid: 5490727
Zerah L, Dourthe L, Cohen-Bittan J et al (2018) Retrospective evaluation of a restrictive transfusion strategy in older adults with hip fracture. J Am Geriatr Soc 66:1151–1157
pubmed: 29676780
Meybohm P, Lindau S, Treskatsch S et al (2019) Liberal transfusion strategy to prevent mortality and anaemia-associated, ischaemic events in elderly non-cardiac surgical patients - the study design of the LIBERAL-Trial. Trials 20:101
pubmed: 30717805 pmcid: 6360712
Wu WC, Smith TS, Henderson WG et al (2010) Operative blood loss, blood transfusion, and 30-day mortality in older patients after major noncardiac surgery. Ann Surg 252:11–17
pubmed: 20505504
Bates AT, Divino C (2015) Laparoscopic surgery in the elderly: a review of the literature. Aging Dis 6:149–155
pubmed: 25821642 pmcid: 4365958
Zhou S, Wang X, Zhao C et al (2019) Laparoscopic vs open colorectal cancer surgery in elderly patients: short- and long-term outcomes and predictors for overall and disease-free survival. BMC Surg 19:137
pubmed: 31521147 pmcid: 6744685
Hoshino N, Fukui Y, Hida K et al (2019) Short-term outcomes of laparoscopic surgery for colorectal cancer in the elderly versus non-elderly: a systematic review and meta-analysis. Int J Colorect Dis 34:377–386
Ceccarelli G, Andolfi E, Biancafarina A et al (2017) Robot-assisted surgery in elderly and very elderly population: our experience in oncologic and general surgery with literature review. Aging Clin Exp Res 29:55–63
pubmed: 27905087
Ljungqvist O, Scott M, Fearon KC (2017) Enhanced recovery after surgery: a review. JAMA Surg 152:292–298
pubmed: 28097305
Parks L, Routt M, De Villiers A (2018) Enhanced recovery after surgery. J Adv Pract Oncol 9:511–519
pubmed: 31086687 pmcid: 6505539
Ljungqvist O, Hubner M (2018) Enhanced recovery after surgery-ERAS-principles, practice and feasibility in the elderly. Aging Clin Exp Res 30:249–252
pubmed: 29453605 pmcid: 5856872
Tejedor P, Pastor C, Gonzalez-Ayora S et al (2018) Short-term outcomes and benefits of ERAS program in elderly patients undergoing colorectal surgery: a case-matched study compared to conventional care. Int J Colorect Dis 33:1251–1258
Inouye SK, van Dyck CH, Alessi CA et al (1990) Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med 113:941–948
pubmed: 2240918
Leentjens AF, Molag ML, Van Munster BC et al (2014) Changing perspectives on delirium care: the new Dutch guideline on delirium. J Psychosom Res 77:240–241
pubmed: 25149034
Bellelli G, Morandi A, Davis DH et al (2014) Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. Age Ageing 43:496–502
pubmed: 24590568 pmcid: 4066613
Bellelli G, Morandi A, Trabucchi M et al (2018) Italian intersociety consensus on prevention, diagnosis, and treatment of delirium in hospitalized older persons. Intern Emerg Med 13:113–121
pubmed: 28741278
Flaherty JH, Tariq SH, Raghavan S et al (2003) A model for managing delirious older inpatients. J Am Geriatr Soc 51:1031–1035
pubmed: 12834527
Aceto P, Lai C, De Crescenzo F et al (2019) Cognitive decline after carotid endarterectomy: systematic review and meta-analysis. Eur J Anaesthiol. https://doi.org/10.1097/EJA.0000000000001130
doi: 10.1097/EJA.0000000000001130
Belrose JC, Noppens RR (2019) Anesthesiology and cognitive impairment: a narrative review of current clinical literature. BMC Anesthesiol 19:241
pubmed: 31881996 pmcid: 6933922
Garcia PS, Duggan EW, McCullough IL et al (2015) Postanesthesia care for the elderly patient. Clin Ther 37:2651–2665
pubmed: 26598176
American Geriatrics Society (2015) Updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 63:2227–2246
Fong HK, Sands LP, Leung JM (2006) The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review. Anesth Analg 102:1255–1266
pubmed: 16551934
Sammons G, Ritchey W (2015) Use of transversus abdominis plane (TAP) blocks for pain management in elderly surgical patients. AORN J 102:493–497
pubmed: 26514706
Miskovic A, Lumb AB (2017) Postoperative pulmonary complications. Br J Anaesth 118:317–334
pubmed: 28186222
Smetana GW, Lawrence VA, Cornell JE (2006) Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians. Ann Intern Med 144:581–595
pubmed: 16618956
Schumann R, Harvey B, Zahedi F et al (2019) Minute ventilation assessment in the PACU is useful to predict postoperative respiratory depression following discharge to the floor: a prospective cohort study. J Clin Anesth 52:93–98
pubmed: 30227321
Eltorai AEM, Baird GL, Eltorai AS et al (2018) Perspectives on incentive spirometry utility and patient protocols. Respir Care 63:519–531
pubmed: 29362216
Eltorai AEM, Baird GL, Eltorai AS et al (2018) Incentive spirometry adherence: a national survey of provider perspectives. Respir Care 63:532–537
pubmed: 29362219
Sieber FE, Barnett SR (2011) Preventing postoperative complications in the elderly. Anesthesiol Clin 29:83–97
pubmed: 21295754 pmcid: 3073675
KDIGO (2018) Clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease. Kidney Int Suppl 8:91–165
Conway LJ, Larson EL (2012) Guidelines to prevent catheter-associated urinary tract infection: 1980 to 2010. Heart Lung 41:271–283
pubmed: 21925731
Patel DN, Felder SI, Luu M et al (2018) Early urinary catheter removal following pelvic colorectal surgery: a prospective, randomized, noninferiority trial. Dis Colon Rectum 61:1180–1186
pubmed: 30192326
Potter J, Klipstein K, Reilly JJ et al (1995) The nutritional status and clinical course of acute admissions to a geriatric unit. Age Ageing 24:131–136
pubmed: 7793335
Herbert G, Perry R, Andersen HK et al (2018) Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications. Cochrane Database Syst Rev 10:Cd004080
pubmed: 30353940
Lewis SJ, Andersen HK, Thomas S (2009) Early enteral nutrition within 24 h of intestinal surgery versus later commencement of feeding: a systematic review and meta-analysis. J Gastrointest Surg 13:569–575
pubmed: 18629592
Volkert D, Beck AM, Cederholm T et al (2019) ESPEN guideline on clinical nutrition and hydration in geriatrics. Clin Nutr 38:10–47
pubmed: 30005900
Lim SC, Koh IAJH (2017) Nutrition and the elderly surgical patients. MOJ Surg 4:114–120
Chiari P, Forni C, Guberti M et al (2017) Predictive factors for pressure ulcers in an older adult population hospitalized for hip fractures: a prognostic cohort study. PLoS ONE 12:e0169909
pubmed: 28068425 pmcid: 5222344
Liu Z, Dumville JC, Norman G et al (2018) Intraoperative interventions for preventing surgical site infection: an overview of cochrane reviews. Cochrane Database Syst Rev 2:Cd012653
pubmed: 29406579
Cataldo MA, Granata G, Petrosillo N (2017) Antibacterial prophylaxis for surgical site infection in the elderly: practical application. Drugs Aging 34:489–498
pubmed: 28589466
Yates AJ Jr (2018) Postoperative prophylactic antibiotics in total joint arthroplasty. Arthroplasty Today 4:130–131
pubmed: 29560408 pmcid: 5859629
Lee P, Min L, Mody L (2014) Perioperative glucose control and infection risk in older surgical patients. Curr Geriatr Rep 3:48–55
pubmed: 25431751 pmcid: 4242425
Ehrenfeld JM, Wanderer JP, Terekhov M et al (2017) A perioperative systems design to improve intraoperative glucose monitoring is associated with a reduction in surgical site infections in a diabetic patient population. Anesthesiology 126:431–440
pubmed: 28106608 pmcid: 28106608
Kwon S, Thompson R, Dellinger P et al (2013) Importance of perioperative glycemic control in general surgery: a report from the Surgical Care and Outcomes Assessment Program. Ann Surg 257:8–14
pubmed: 23235393 pmcid: 4208433
Evans CH, Lee J, Ruhlman MK (2015) Optimal glucose management in the perioperative period. Surg Clin N Am 95:337–354
pubmed: 25814110
Goncalves-Bradley DC, Lannin NA, Clemson LM et al (2016) Discharge planning from hospital. Cochrane Database Syst Rev 2016:Cd000313
pmcid: 7073416
Zurlo A, Zuliani G (2018) Management of care transition and hospital discharge. Aging Clin Exp Res 30:263–270
pubmed: 29313293
McNab D, Bowie P, Ross A et al (2018) Systematic review and meta-analysis of the effectiveness of pharmacist-led medication reconciliation in the community after hospital discharge. BMJ Qual Saf 27:308–320
pubmed: 29248878
Mixon AS, Neal E, Bell S et al (2015) Care transitions: a leverage point for safe and effective medication use in older adults—a mini-review. Gerontology 61:32–40
pubmed: 25277280
Krumholz HM (2013) Post-hospital syndrome–an acquired, transient condition of generalized risk. N Engl J Med 368:100–102
pubmed: 23301730 pmcid: 3688067
Brownlee SA, Blackwell RH, Blanco BA et al (2017) Impact of post-hospital syndrome on outcomes following elective, ambulatory surgery. Ann Surg 266:274–279
pubmed: 27537532 pmcid: 5315678
Robinson TN, Wallace JI, Wu DS et al (2011) Accumulated frailty characteristics predict postoperative discharge institutionalization in the geriatric patient. J Am Coll Surg 213:37–42
pubmed: 21435921 pmcid: 3132184
Rid A, Wesley R, Pavlick M et al (2015) Patients' priorities for treatment decision making during periods of incapacity: quantitative survey. Palliat Support Care 13:1165–1183
pubmed: 25273677
De Blasio E, Raffaelo de Gaudio A, Petrini F et al (2019) Strategie perioperatorie: presa in carico dell’anziano con gravi comorbilità e fase avanzata di malattia con patologia chirurgica acuta: SIAARTI 2019 [Perioperative strategies: taking care of the elderly with severe comorbidities and advanced stage of disease with acute surgical pathology]. https://www.siaarti.it/SiteAssets/Ricerca/Strategie-perioperatorie-presa-in-carico-dell-anziano-con-gravi-comorbilità-e-fase-avanzata-di-malattia-con-patologia-chir/Strategie%2520perioperatorie%2520-%2520SIAARTI-SIC.pdf. Accessed 26 Feb 2020

Auteurs

Paola Aceto (P)

Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Università Cattolica del Sacro Cuore, Rome, Italy.

Raffaele Antonelli Incalzi (R)

Policlinico Universitario Campus Biomedico, Rome, Italy.

Gabriella Bettelli (G)

Past Director Geriatric Surgery Area and Anaesthesia Dpt., INRCA, Italian National Research Centre on Aging, Ancona, Italy.

Michele Carron (M)

Università degli Studi di Padova, Padua, Italy.

Fernando Chiumiento (F)

ASL Salerno, Salerno, Italy.

Antonio Corcione (A)

Monaldi-Ospedale Dei Colli, Naples, Italy.

Antonio Crucitti (A)

Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Università Cattolica del Sacro Cuore, Rome, Italy.

Stefania Maggi (S)

CNR, Institute of Neuroscience, Aging Branch, Padua, Italy.

Marco Montorsi (M)

Humanitas University and Research Hospital IRCCS, Milan, Italy.

Maria Caterina Pace (MC)

Università degli Studi "Luigi Vanvitelli", Naples, Italy.

Flavia Petrini (F)

Università degli Studi G.d'Annunzio, Chieti, Italy.

Concezione Tommasino (C)

Università degli Studi di Milano, Milan, Italy.

Marco Trabucchi (M)

Università degli Studi di Tor Vergata, Rome, Italy.

Stefano Volpato (S)

Università degli Studi di Ferrara, Ferrara, Italy. vlt@unife.it.

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