Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy.
Adult
Aged
Aged, 80 and over
COVID-19
Coronavirus Infections
/ complications
Female
Hospitalization
/ statistics & numerical data
Humans
Internal Medicine
/ methods
Italy
/ epidemiology
Liver
/ physiopathology
Liver Failure
/ complications
Male
Middle Aged
Pandemics
Patients' Rooms
/ organization & administration
Pneumonia, Viral
/ complications
Retrospective Studies
Acute respiratory failure
Coronavirus
Hepatitis
Severe acute respiratory syndrome
Journal
Internal and emergency medicine
ISSN: 1970-9366
Titre abrégé: Intern Emerg Med
Pays: Italy
ID NLM: 101263418
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
27
05
2020
accepted:
27
06
2020
pubmed:
12
7
2020
medline:
25
11
2020
entrez:
12
7
2020
Statut:
ppublish
Résumé
Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25-97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was > 50 mU/ml, gamma-glutamyl transpeptidase (GGT) > 50 mU/ml, or total bilirubin > 1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO
Identifiants
pubmed: 32651938
doi: 10.1007/s11739-020-02425-w
pii: 10.1007/s11739-020-02425-w
pmc: PMC7348571
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1399-1407Investigateurs
Gaetano Bergamaschi
(G)
Giampiera Bertolino
(G)
Silvia Codega
(S)
Filippo Costanzo
(F)
Roberto Cresci
(R)
Giuseppe Derosa
(G)
Francesco Falaschi
(F)
Carmine Iadarola
(C)
Elisabetta Lovati
(E)
Pietro Carlo Lucotti
(PC)
Alessandra Martignoni
(A)
Amedeo Mugellini
(A)
Chiara Muggia
(C)
Patrizia Noris
(P)
Elisabetta Pagani
(E)
Ilaria Palumbo
(I)
Alessandro Pecci
(A)
Tiziano Perrone
(T)
Carla Pieresca
(C)
Paola Stefania Preti
(PS)
Mariaconcetta Russo
(M)
Carmelo Sgarlata
(C)
Luisa Siciliani
(L)
Andrea Staniscia
(A)
Francesca Torello Vjera
(F)
Giovanna Achilli
(G)
Andrea Agostinelli
(A)
Valentina Antoci
(V)
Alessia Ballesio
(A)
Francesco Banfi
(F)
Chiara Barteselli
(C)
Irene Benedetti
(I)
Michele Brattoli
(M)
Francesca Calabretta
(F)
Ginevra Cambiè
(G)
Roberta Canta
(R)
Federico Conca
(F)
Luigi Coppola
(L)
Elisa Maria Cremonte
(EM)
Gabriele Croce
(G)
Virginia Del Rio
(V)
Francesco Di Terlizzi
(F)
Maria Giovanna Ferrari
(MG)
Sara Ferrari
(S)
Anna Fiengo
(A)
Tommaso Forni
(T)
Giulia Freddi
(G)
Chiara Frigerio
(C)
Federica Fumoso
(F)
Alessandra Fusco
(A)
Margherita Gabba
(M)
Matteo Garolfi
(M)
Antonella Gentile
(A)
Giulia Gori
(G)
Giacomo Grandi
(G)
Paolo Grimaldi
(P)
Alice Lampugnani
(A)
Francesco Lapia
(F)
Federica Lepore
(F)
Gianluca Lettieri
(G)
Jacopo Mambella
(J)
Chiara Mercanti
(C)
Francesco Mordà
(F)
Alba Nardone
(A)
Luca Pace
(L)
Lucia Padovini
(L)
Alessandro Parodi
(A)
Lavinia Pitotti
(L)
Margherita Reduzzi
(M)
Giovanni Rigano
(G)
Giorgio Rotola
(G)
Umberto Sabatini
(U)
Lucia Salvi
(L)
Giovanni Santacroce
(G)
Jessica Savioli
(J)
Simone Soriano
(S)
Carmine Spataro
(C)
Debora Stefani
(D)
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