The Cerebellar Nuclei and Dexterous Limb Movements.
Ataxia
Cerebellar nuclei
Dysmetria
Grasp
Internal copy
Reach
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
received:
22
02
2020
revised:
03
06
2020
accepted:
30
06
2020
pubmed:
12
7
2020
medline:
15
5
2021
entrez:
12
7
2020
Statut:
ppublish
Résumé
Dexterous forelimb movements like reaching, grasping, and manipulating objects are fundamental building blocks of the mammalian motor repertoire. These behaviors are essential to everyday activities, and their elaboration underlies incredible accomplishments by human beings in art and sport. Moreover, the susceptibility of these behaviors to damage and disease of the nervous system can lead to debilitating deficits, highlighting a need for a better understanding of function and dysfunction in sensorimotor control. The cerebellum is central to coordinating limb movements, as defined in large part by Joseph Babinski and Gordon Holmes describing motor impairment in patients with cerebellar lesions over 100 years ago (Babinski, 1902; Holmes, 1917), and supported by many important human and animal studies that have been conducted since. Here, with a focus on output pathways of the cerebellar nuclei across mammalian species, we describe forelimb movement deficits observed when cerebellar circuits are perturbed, the mechanisms through which these circuits influence motor output, and key challenges in defining how the cerebellum refines limb movement.
Identifiants
pubmed: 32652173
pii: S0306-4522(20)30427-9
doi: 10.1016/j.neuroscience.2020.06.046
pmc: PMC7688491
mid: NIHMS1610933
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
168-183Subventions
Organisme : NINDS NIH HHS
ID : DP2 NS105555
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS111479
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS112959
Pays : United States
Informations de copyright
Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
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