Development of low dose micro-tablets by high shear wet granulation process.
Content uniformity
Dose flexibility
Drug particle size
High shear wet granulation
Ibuprofen (PubChem CID: 3672)
Micro-dose
Micro-tablets
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Sep 2020
25 Sep 2020
Historique:
received:
02
05
2020
revised:
17
06
2020
accepted:
20
06
2020
pubmed:
12
7
2020
medline:
22
6
2021
entrez:
12
7
2020
Statut:
ppublish
Résumé
Low dose micro-tablets with acceptable quality attributes, specifically content uniformity (CU), would not only enhance the dose flexibility in the clinic, but also decrease excipient burden in pediatric population. Considering the CU challenges associated with directly compressed low dose micro-tablets, in this study, high shear wet granulation (HSWG) process was evaluated to manufacture micro-tablets with reduced CU variability. The impact of active pharmaceutical ingredient (API) particle size (D
Identifiants
pubmed: 32652180
pii: S0378-5173(20)30555-X
doi: 10.1016/j.ijpharm.2020.119571
pii:
doi:
Substances chimiques
Excipients
0
Tablets
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119571Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.