Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19.
Anti-Inflammatory Agents, Non-Steroidal
/ administration & dosage
Betacoronavirus
/ pathogenicity
COVID-19
Coronavirus Infections
/ diet therapy
Cytokine Release Syndrome
/ diet therapy
Dietary Supplements
Disseminated Intravascular Coagulation
/ diet therapy
Docosahexaenoic Acids
/ administration & dosage
Eicosapentaenoic Acid
/ administration & dosage
Humans
Hypoxia
/ diet therapy
Leukopenia
/ diet therapy
Oxidative Stress
Pandemics
Pneumonia, Viral
/ diet therapy
Randomized Controlled Trials as Topic
Reactive Oxygen Species
/ antagonists & inhibitors
SARS-CoV-2
DHA
EPA
Inflammation
Oxidative stress
SARS-CoV-2
SPMs
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
20 08 2020
20 08 2020
Historique:
received:
03
06
2020
revised:
26
06
2020
accepted:
05
07
2020
pubmed:
13
7
2020
medline:
28
8
2020
entrez:
13
7
2020
Statut:
ppublish
Résumé
Studies have shown that infection, excessive coagulation, cytokine storm, leukopenia, lymphopenia, hypoxemia and oxidative stress have also been observed in critically ill Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) patients in addition to the onset symptoms. There are still no approved drugs or vaccines. Dietary supplements could possibly improve the patient's recovery. Omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), present an anti-inflammatory effect that could ameliorate some patients need for intensive care unit (ICU) admission. EPA and DHA replace arachidonic acid (ARA) in the phospholipid membranes. When oxidized by enzymes, EPA and DHA contribute to the synthesis of less inflammatory eicosanoids and specialized pro-resolving lipid mediators (SPMs), such as resolvins, maresins and protectins. This reduces inflammation. In contrast, some studies have reported that EPA and DHA can make cell membranes more susceptible to non-enzymatic oxidation mediated by reactive oxygen species, leading to the formation of potentially toxic oxidation products and increasing the oxidative stress. Although the inflammatory resolution improved by EPA and DHA could contribute to the recovery of patients infected with SARS-CoV-2, Omega-3 fatty acids supplementation cannot be recommended before randomized and controlled trials are carried out.
Identifiants
pubmed: 32653511
pii: S0891-5849(20)31141-2
doi: 10.1016/j.freeradbiomed.2020.07.005
pmc: PMC7350587
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Reactive Oxygen Species
0
Docosahexaenoic Acids
25167-62-8
Eicosapentaenoic Acid
AAN7QOV9EA
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
190-199Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no conflict of interest to declare.
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