Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective.
Apoptosis
Cyclooxygenase
Gastropathy
Inflammation
Mitochondria
NSAID
Organ damage
Prostaglandin
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
27
04
2020
revised:
03
07
2020
accepted:
07
07
2020
pubmed:
13
7
2020
medline:
1
1
2021
entrez:
13
7
2020
Statut:
ppublish
Résumé
Owing to the efficacy in reducing pain and inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most popularly used medicines confirming their position in the WHO's Model List of Essential Medicines. With escalating musculoskeletal complications, as evident from 2016 Global Burden of Disease data, NSAID usage is evidently unavoidable. Apart from analgesic, anti-inflammatory and antipyretic efficacies, NSAIDs are further documented to offer protection against diverse critical disorders including cancer and heart attacks. However, data from multiple placebo-controlled trials and meta-analyses studies alarmingly signify the adverse effects of NSAIDs in gastrointestinal, cardiovascular, hepatic, renal, cerebral and pulmonary complications. Although extensive research has elucidated the mechanisms underlying the clinical hazards of NSAIDs, no review has extensively collated the outcomes on various multiorgan toxicities of these drugs together. In this regard, the present review provides a comprehensive insight of the existing knowledge and recent developments on NSAID-induced organ damage. It precisely encompasses the current understanding of structure, classification and mode of action of NSAIDs while reiterating on the emerging instances of NSAID drug repurposing along with pharmacophore modification aimed at safer usage of NSAIDs where toxic effects are tamed without compromising the clinical benefits. The review does not intend to vilify these 'wonder drugs'; rather provides a careful understanding of their side-effects which would be beneficial in evaluating the risk-benefit threshold while rationally using NSAIDs at safer dose and duration.
Identifiants
pubmed: 32653589
pii: S0006-2952(20)30383-X
doi: 10.1016/j.bcp.2020.114147
pmc: PMC7347500
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Cyclooxygenase 2 Inhibitors
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
114147Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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