Necrotic cell death increases the release of macrophage migration inhibitory factor by monocytes/macrophages.
cytokines
inflammasome
inflammation
necroptosis
necrosis
pyroptosis
Journal
Immunology and cell biology
ISSN: 1440-1711
Titre abrégé: Immunol Cell Biol
Pays: United States
ID NLM: 8706300
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
13
05
2020
revised:
16
06
2020
accepted:
09
07
2020
pubmed:
13
7
2020
medline:
25
8
2021
entrez:
13
7
2020
Statut:
ppublish
Résumé
Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory molecule with both cytokine and noncytokine activity. MIF is constitutively released from multiple cell types via an unconventional secretory pathway that is not well defined. Here, we looked at MIF release from human and mouse monocytes/macrophages in response to different stimuli. While MIF release was not significantly altered in response to lipopolysaccharide or heat-killed Escherichia coli, cytotoxic stimuli strongly promoted release of MIF. MIF release was highly upregulated in cells undergoing necrosis, necroptosis and NLRP3 inflammasome-dependent pyroptosis. Our data suggest that cell death represents a major route for MIF release from myeloid cells. The functional significance of these findings and their potential importance in the context of autoimmune and inflammatory diseases warrant further investigation.
Substances chimiques
Macrophage Migration-Inhibitory Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
782-790Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 Australian and New Zealand Society for Immunology Inc.
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