Genetics and Signaling Pathways of Laminitis.

Animals Foot Diseases / genetics Hoof and Claw / metabolism Horse Diseases / genetics Horses Inflammation / genetics Signal Transduction
Autoinflammatory disease Fibrosis Founder Hoof equine Horse Proteostasis

Journal

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
Titre abrégé: Vet Clin North Am Equine Pract
Pays: United States
ID NLM: 8511904

Informations de publication

Date de publication:
Aug 2020
Historique:
entrez: 14 7 2020
pubmed: 14 7 2020
medline: 4 8 2020
Statut: ppublish

Résumé

Laminitis is a devastating disease with diverse etiologies and few, if any, effective treatments. Gene expression and hypothesis-generating genomic studies have provided a fresh look at the key molecular players at crucial timepoints in diverse experimental and naturally affected tissues. We summarize findings to date, and propose a unifying model of the laminitis disease process that includes several pathogenesis concepts shared with other diseases of epidermal and epithelial tissues. The value of these new pathways as potential therapeutic targets is exciting but will require careful future work to validate new methods and launch systematic clinical trials.

Identifiants

DOI: 10.1016/j.cveq.2020.04.001 PMID: 32654786
pubmed: 32654786
pii: S0749-0739(20)30026-2
doi: 10.1016/j.cveq.2020.04.001
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

379-394

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Hannah Galantino-Homer (H)

Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, USA.

Samantha A Brooks (SA)

Department of Animal Sciences, UF Genetics Institute, University of Florida, Gainesville, FL, USA. Electronic address: samantha.brooks@ufl.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Genetics and Signaling Pathways of Laminitis.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du pied › Genetics and Signaling Pathways of Laminitis.
questionsmedicales.fr › Structures anatomiques de l'animal › Sabot et griffe › Genetics and Signaling Pathways of Laminitis.
questionsmedicales.fr › Maladies de l'animal › Maladies des chevaux › Genetics and Signaling Pathways of Laminitis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Perissodactyla › Equidae › Equus caballus › Genetics and Signaling Pathways of Laminitis.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Genetics and Signaling Pathways of Laminitis.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Genetics and Signaling Pathways of Laminitis.