Decreased neural inhibitory state in fibromyalgia pain: A cross-sectional study.

Chronic Pain Cross-Sectional Studies Female Fibromyalgia / complications Humans Pain Measurement Quality of Life
Biomarker Chronic pain Conditioned pain modulation Electroencephalography Event-related desynchronization Fibromyalgia Neural inhibitory state Transcranial magnetic stimulation

Journal

Neurophysiologie clinique = Clinical neurophysiology
ISSN: 1769-7131
Titre abrégé: Neurophysiol Clin
Pays: France
ID NLM: 8804532

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 03 04 2020
revised: 09 06 2020
accepted: 10 06 2020
pubmed: 14 7 2020
medline: 16 9 2021
entrez: 14 7 2020
Statut: ppublish

Résumé

Chronic pain is one of the most common and challenging symptoms in fibromyalgia (FM). Currently, self-reported pain is the main criterion used by clinicians assessing patients with pain. However, it is subjective, and multiple factors can affect pain levels. In this study, we investigated the neural correlates of FM pain using conditioned pain modulation (CPM), electroencephalography (EEG), and transcranial magnetic stimulation (TMS). In this cross-sectional neurophysiological analysis of a randomized, double-blind controlled trial, 36 patients with fibromyalgia were included. We analyzed CPM, EEG variables and TMS measures and their correlation with pain levels as measured by a visual analog scale. Univariate and multivariate linear regression analyses were performed to identify the predictors of pain severity. We found: (1) no association between pain levels and CPM; (2) an association between reduced alpha and beta power over the central region in resting-EEG and higher pain levels; (3) an association between smaller event-related desynchronization (ERD) responses in theta and delta bands over the central region and higher pain levels; (4) an association between smaller ERD responses in theta and delta bands and smaller intracortical inhibition and higher intracortical facilitation ratios; (5) an association between smaller ERD responses in delta band and reduced CPM. Our results do not support CPM as a biomarker for pain intensity in FM. However, our specific EEG findings showing the relationship between pain, CPM and TMS measures suggest that FM leads to a disruption of inhibitory neural modulators and thus support CPM as a likely predictive marker of disrupted pain modulation system. These neurophysiological markers need to be further explored in potential future trials as to find novel targets for the treatment of FM.

Identifiants

DOI: 10.1016/j.neucli.2020.06.002 PMID: 32654884 PMC: PMC7494538
pubmed: 32654884
pii: S0987-7053(20)30058-7
doi: 10.1016/j.neucli.2020.06.002
pmc: PMC7494538
mid: NIHMS1612550
pii:
doi:

Types de publication

Journal Article Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

IM

Pagination

279-288

Subventions

Organisme : NCCIH NIH HHS
ID : R01 AT009491
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Références

Schmerz. 2012 Feb;26(1):8-15
pubmed: 22134376
Electroencephalogr Clin Neurophysiol. 1994 Oct;93(5):380-9
pubmed: 7525246
Pain Med. 2016 Feb 26;17(6):1058-1068
pubmed: 26921889
Prog Brain Res. 2006;159:211-22
pubmed: 17071233
J Oral Rehabil. 2016 Feb;43(2):89-95
pubmed: 26337788
Arthritis Rheum. 1990 Feb;33(2):160-72
pubmed: 2306288
Elife. 2015 Dec 02;4:e10774
pubmed: 26633811
J Headache Pain. 2016 Dec;17(1):102
pubmed: 27807767
BMJ Open. 2019 Oct 30;9(10):e032710
pubmed: 31672712
Pain. 2008 May;136(1-2):142-9
pubmed: 17720319
Neurophysiol Clin. 2012 Oct;42(5):345-53
pubmed: 23040705
Front Neurol. 2018 Oct 05;9:822
pubmed: 30344504
Front Hum Neurosci. 2016 Mar 14;10:111
pubmed: 27014041
Neurophysiol Clin. 2012 Oct;42(5):267-80
pubmed: 23040698
PLoS One. 2017 Jun 26;12(6):e0178516
pubmed: 28650974
Curr Opin Neurobiol. 2007 Dec;17(6):649-55
pubmed: 18339546
Pain. 2010 Jun;149(3):495-500
pubmed: 20356675
Neuroimage. 2016 Oct 1;139:439-449
pubmed: 27374370
Pain. 2015 Apr;156 Suppl 1:S24-31
pubmed: 25789433
Nat Rev Neurosci. 2017 Jan 20;18(2):113
pubmed: 28704354
Electroencephalogr Clin Neurophysiol. 1994 Jul;91(1):1-5
pubmed: 7517838
Brain. 2006 Jan;129(Pt 1):55-64
pubmed: 16183660
J Neurophysiol. 2009 Aug;102(2):1115-20
pubmed: 19458142
Neurosci Res. 2005 Dec;53(4):428-35
pubmed: 16213048
Pain. 2019 Dec;160(12):2751-2765
pubmed: 31356455
J Pain Res. 2013 Nov 25;6:815-24
pubmed: 24379694
Semin Arthritis Rheum. 2014 Aug;44(1):68-75
pubmed: 24508406
Electroencephalogr Clin Neurophysiol. 1977 Jun;42(6):817-26
pubmed: 67933
Eur J Pain. 2011 May;15(5):491-7
pubmed: 21035364
J Clin Psychiatry. 2011 Feb;72(2):219-24
pubmed: 20816025
Clin Neurophysiol. 2000 Oct;111(10):1719-32
pubmed: 11018485
Clin Neurophysiol. 2020 Mar;131(3):635-641
pubmed: 31978848
Pain. 2016 Aug;157(8):1704-10
pubmed: 27045524
BMC Musculoskelet Disord. 2007 Mar 09;8:27
pubmed: 17349056
Curr Opin Neurobiol. 2018 Apr;49:33-41
pubmed: 29172091
J Physiol. 1999 Apr 15;516 ( Pt 2):559-70
pubmed: 10087353
Clin Neurophysiol. 1999 Nov;110(11):1842-57
pubmed: 10576479
Pain. 2005 Mar;114(1-2):295-302
pubmed: 15733656
Arch Dis Child. 2014 May;99(5):474-80
pubmed: 24554056
J Neurosci. 2013 Nov 20;33(47):18515-30
pubmed: 24259574
Arthritis Rheum. 1992 May;35(5):550-6
pubmed: 1374252
J Am Acad Orthop Surg Glob Res Rev. 2018 Mar 23;2(3):e088
pubmed: 30211382
Pain. 2012 Aug;153(8):1555-9
pubmed: 22464695
Nat Neurosci. 2017 Jan;20(1):82-89
pubmed: 27798633
Pain. 2017 Jan;158(1):34-47
pubmed: 27583567
Semin Arthritis Rheum. 2016 Dec;46(3):319-329
pubmed: 27916278
Front Hum Neurosci. 2016 Jul 15;10:357
pubmed: 27471458
J Physiol. 1993 Nov;471:501-19
pubmed: 8120818
Clin Neurophysiol. 2010 May;121(5):777-83
pubmed: 20110193
Neuroimage. 2007 Feb 15;34(4):1428-37
pubmed: 17178235
Curr Opin Support Palliat Care. 2015 Jun;9(2):131-7
pubmed: 25699686
Pain. 2019 Dec;160(12):2679-2690
pubmed: 31365469
Eur J Pain. 2018 Jan;22(1):49-57
pubmed: 28758313
Clin EEG Neurosci. 2016 Oct;47(4):276-290
pubmed: 26251456
J Pain. 2014 Jun;15(6):645-55
pubmed: 24589821
PLoS One. 2016 Feb 25;11(2):e0149085
pubmed: 26914356
Neuroimage. 2014 May 1;91:360-5
pubmed: 24440529
Pain Physician. 2015 May-Jun;18(3):E389-401
pubmed: 26000686
Pharmacol Biochem Behav. 2002 Oct;73(3):557-63
pubmed: 12151030
Curr Opin Neurobiol. 2010 Apr;20(2):156-65
pubmed: 20359884
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Feb 4;65:158-71
pubmed: 26456730
Sci Transl Med. 2011 Jan 12;3(65):65ps1
pubmed: 21228395
Rev Neurosci. 2010;21(4):289-98
pubmed: 21086761
J Pain. 2012 Oct;13(10):936-44
pubmed: 22981090
Ann Phys Rehabil Med. 2015 Sep;58(4):208-213
pubmed: 26319963
J Neurosci Methods. 2004 Mar 15;134(1):9-21
pubmed: 15102499

Auteurs

Elif Uygur-Kucukseymen (E)

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 96-13th Street, Charlestown, Boston, MA, USA.

Luis Castelo-Branco (L)

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 96-13th Street, Charlestown, Boston, MA, USA.

Kevin Pacheco-Barrios (K)

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 96-13th Street, Charlestown, Boston, MA, USA; Universidad San Ignacio de Loyola, Vicerrectorado de Investigación, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Lima, Peru.

Maria Alejandra Luna-Cuadros (MA)

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 96-13th Street, Charlestown, Boston, MA, USA.

Alejandra Cardenas-Rojas (A)

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 96-13th Street, Charlestown, Boston, MA, USA.

Stefano Giannoni-Luza (S)

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 96-13th Street, Charlestown, Boston, MA, USA.

Huiyan Zeng (H)

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 96-13th Street, Charlestown, Boston, MA, USA; Department of Endocrinology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

Anna Carolyna Gianlorenco (AC)

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 96-13th Street, Charlestown, Boston, MA, USA; Department of Physical Therapy, Federal University of Sao Carlos, Brazil.

Marina Gnoatto-Medeiros (M)

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 96-13th Street, Charlestown, Boston, MA, USA.

Emad Salman Shaikh (ES)

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 96-13th Street, Charlestown, Boston, MA, USA.

Wolnei Caumo (W)

School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil Laboratory of Pain and Neuromodulation at Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.

Felipe Fregni (F)

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 96-13th Street, Charlestown, Boston, MA, USA. Electronic address: Fregni.Felipe@mgh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Douleur chronique › Decreased neural inhibitory state in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Decreased neural inhibitory state in...
questionsmedicales.fr › Maladies du système nerveux › Maladies neuromusculaires › Maladies musculaires › Fibromyalgie › Decreased neural inhibitory state in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Decreased neural inhibitory state in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Examen physique › Examen neurologique › Mesure de la douleur › Decreased neural inhibitory state in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Decreased neural inhibitory state in...